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  1. Home
  2. MLB Picks
  3. San Francisco Giants vs Milwaukee Brewers
Fri 8:10 PM ET
San Francisco Giants logo
San Francisco
Giants4
C. Whisenhunt LHP
versus
Milwaukee Brewers logo
Milwaukee
Brewers5
J. Quintana LHP
Final
Team123456789T
San Francisco Giants1100000114
Milwaukee Brewers00020

San Francisco Giants vs Milwaukee Brewers Betting Picks & Predictions

Game time: August 22, 2025 at 8:10 PM ET

Venue: American Family Field — Milwaukee, Wisconsin

Article updated Aug 22, 11:45 PM EDT

Published by SportsJaw Editorial Team

The Giants will face off against the Brewers in Milwaukee as the Brewers, currently the hottest team in baseball, are leading the NL Central Division with the best record in

Game outlook

The Giants will face off against the Brewers in Milwaukee as the Brewers, currently the hottest team in baseball, are leading the NL Central Division with the best record in baseball. The Giants, on the other hand, have lost three consecutive games and are sitting in fourth place in the NL West Division. The pitching matchup for the series opener will feature Carson Whisenhunt for the Giants and Jose Quintana for the Brewers. The game is set to begin at 8:10 PM EST. Check out more details in this Giants at Brewers prediction and maximize your bankroll with our top picks.

Betting Odds

Moneyline: Giants +153 | Brewers -171

Spread: Giants +1.5 (-130) | Brewers -1.5 (+111)

Total: Over/Under 9 (-110)

Based on the moneyline, the implied probability that Milwaukee will win straight-up is 63%.

San Francisco Giants

The San Francisco Giants, who previously made a significant trade to acquire Rafael Devers, are now struggling and find themselves in fourth place in the NL West. Despite high expectations following the trade, the team's performance has declined, and they now face the reality of being spoilers for the remainder of the season. Their recent loss to the Padres, where starter Justin Verlander struggled, further highlights the team's current struggles. Looking ahead, lefty Carson Whisenhunt will start in the upcoming game against the Brewers. The Giants will need to overcome key injuries to several players, including Matt Chapman, Ryan Murphy, Ethan Small, Tom Murphy, and Cole Waites.

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MLB · San Francisco Giants at Milwaukee Brewers

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Milwaukee Brewers

The Milwaukee Brewers have been on a hot streak, winning a franchise-record 14 straight games and taking a commanding lead in the NL Central Division. Despite a rough patch in Chicago, they bounced back with a 4-1 win on Thursday, led by Brice Turang's strong performance. The Brewers aim to continue their success against the Giants, starting with southpaw Jose Quintana on Friday night. Quintana has a solid record this season and the Brewers have won three of his last five starts. Key injuries include 1B Rhys Hoskins being out.

Brewers Poised to Dominate Giants at Home with Strong Pitching and Offense

This weekend, the Brewers are poised to capitalize on their home field advantage against the struggling Giants, led by rookie lefty Whisenhunt. With a strong record of 42-20 at home this season, the Brewers hold a clear advantage. Whisenhunt, with an ERA of 5.02 and a history of giving up home runs, is likely to struggle against the Brewers' potent lineup. Starting pitcher Quintana has also shown strong performances recently, with a 1-0 record against the Giants and an impressive ERA of 1.50. His past success against the Giants, where he allowed just one run in six innings, bodes well for the Brewers. With Quintana on the mound and the Brewers' hot offense, the Giants are expected to face a tough challenge. In this matchup, the smart choice is to take the Giants with the money line.

SportsJawGame Predictions
Predicted score

Unavailable for this preview

Projected winnerUnavailableConfidencelow
Pick on the Spread

Published pick: Unavailable

Pick on the Total

Published pick: Unavailable

#SanFranciscoGiants#MilwaukeeBrewers

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Written by

SportsJaw Editorial Team

SportsJaw published this archived preview from its original game-day article. Its prediction and quoted lines are preserved as written.

About our editorial process

SportsJaw Giants vs Brewers archived game preview contains historical odds and availability that may no longer be current. View history of past Giants vs Brewers matchups or learn how our predictions work.

Current matchup data

Lines, trends and availability

Line movement since open

  • Moneyline · San Francisco Giants+146 → +155Moved
  • Moneyline · Milwaukee Brewers-172 → -182Moved
  • Spread · San Francisco Giants+1.5 (-145) → +1.5 (-130)Moved
  • Spread · Milwaukee Brewers-1.5 (+125) → -1.5 (+110)Moved
  • Total · Over8.5 (-110) → 9 (-110)Moved
  • Total · Under8.5 (-110) → 9 (-110)Moved

ATS and O/U trends

San Francisco Giants
65-97 matchup record · 2-7-1 ATS · 5-5-0 O/U
Last 10 completed games on file
Milwaukee Brewers
103-59 matchup record · 6-4-0 ATS · 5-5-0 O/U
Last 10 completed games on file

Injuries and availability

From the published research (2025-08-23T03:45:51.165Z). Availability may have changed; review the cited sources.

The San Francisco Giants, who previously made a significant trade to acquire Rafael Devers, are now struggling and find themselves in fourth place in the NL West. Despite high expectations following the trade, the team's performance has declined, and they now face the reality of being spoilers for the remainder of the season. Their recent loss to the Padres, where starter Justin Verlander struggled, further highlights the team's current struggles. Looking ahead, lefty Carson Whisenhunt will start in the upcoming game against the Brewers. The Giants will need to overcome key injuries to several players, including Matt Chapman, Ryan Murphy, Ethan Small, Tom Murphy, and Cole Waites.

The Milwaukee Brewers have been on a hot streak, winning a franchise-record 14 straight games and taking a commanding lead in the NL Central Division. Despite a rough patch in Chicago, they bounced back with a 4-1 win on Thursday, led by Brice Turang's strong performance. The Brewers aim to continue their success against the Giants, starting with southpaw Jose Quintana on Friday night. Quintana has a solid record this season and the Brewers have won three of his last five starts. Key injuries include 1B Rhys Hoskins being out.

Recent head-to-head

No completed head-to-head result is available in the current history window.

Final result

Matchup pick recap

Milwaukee Brewers defeated San Francisco Giants 5-4

Milwaukee Brewers defeated San Francisco Giants 5-4 on August 22, 2025, a 1-run decision in the series. Milwaukee Brewers' strongest period was the 4th inning, when it outscored its opponent 2-0. Against SportsJaw's recorded San Francisco Giants +1.5 (-130) spread, San Francisco Giants covered, while the 9 total pushed.

SportsJaw editorial picks

  • Projected winnerNo published selectionUnavailable

Tipster picks

No graded public tipster picks were recorded for this matchup.