Cleveland Guardians vs Arizona Diamondbacks Betting Picks & Predictions

Game outlook

On Tuesday, August 19, 2025, the Cleveland Guardians will be facing off against the Arizona Diamondbacks in an interleague battle at Chase Field in Phoenix, Arizona. This article offers a preview of the Guardians vs. Diamondbacks matchup, part of a three-game regular-season series between the two teams. The analysis excludes Monday's opener and was published before those results were known. For more information on this game and other MLB picks for Tuesday's card, continue reading. The first pitch at Chase Field is scheduled for 9:40 PM ET.

Betting Odds

Moneyline: Guardians +108 | Diamondbacks -120

Spread: Guardians +1.5 (-195) | Diamondbacks -1.5 (+170)

Total: Over/Under 8.5 (-110)

Based on the moneyline, the implied probability that Arizona will win straight-up is 55%.

Cleveland Guardians

The Cleveland Guardians were swept by the Atlanta Braves in a three-game series over the weekend, scoring just five runs while yielding 17. This has placed them 3.5 games behind the bottom wild card in the American League. Over the last 10 days, the Guardians have struggled offensively with a .218/.294/.367 triple-slash and 85 wRC+. The bullpen has posted a 3.79 ERA, 1.26 WHIP, and .241 batting average against during this time. Tanner Bibee is set to start on Tuesday night, with a 4.54 ERA and 1.29 WHIP in 24 starts this season. He has allowed four or more runs in seven of his last eight starts. In his only previous meeting with the Arizona Diamondbacks in 2023, Bibee threw five innings of three-run ball in a winning effort. Five players from the Diamondbacks team have faced Bibee before, with a combined two singles and a double in 12 at-bats.