Chicago Cubs vs
Toronto Blue JaysPredictions & Preview

Blue Jays Favored to Win Interleague Showdown Against Cubs in 2025 MLB Season Opener

The 2025 Major League Baseball season kicks off on Wednesday, August 13 with the Chicago Cubs facing off against the Toronto Blue Jays at Rogers Centre in Toronto, Ontario. This interleague showdown is part of a three-game series, with the Blue Jays favored to win with a -130 moneyline. The total runs are set at 8.5. For a detailed prediction of this matchup and more MLB picks for Wednesday's games, be sure to read on. The game is scheduled to begin at 7:07 PM ET.

Betting Odds

• Moneyline: Cubs +113 | Blue Jays -127
• Spread: Cubs +1.5 (-180) | Blue Jays -1.5 (+157)
• Total: Over/Under 8.5 (-110)
• Based on the moneyline, the implied probability that Toronto will win straight-up is 56%.

Chicago Cubs

The Chicago Cubs are currently facing challenges in the race for the NL Central title, having lost successive series against the Cincinnati Reds and St. Louis Cardinals. Their recent offensive performance has been lackluster, with a .232/.283/.364 slash line in August. The bullpen also needs improvement, with a 4.11 ERA and a .242 batting average against this month. Pitcher Cade Horton is set to start in the upcoming game at Rogers Centre, boasting a 6-3 record with a 3.18 ERA this season. He has been in excellent form recently, not allowing a run in his last four outings. Horton will look to secure his fourth consecutive win on Wednesday night.

Toronto Blue Jays

The Toronto Blue Jays had a successful week, going 4-2 with a sweep against the Colorado Rockies and taking two out of three against the Los Angeles Dodgers. Despite a loss, they managed to avoid a sweep by winning the last game of the series. Their impressive record in August includes a strong batting average and multiple extra-base hits. However, their bullpen has struggled with a high ERA and WHIP. Kevin Gausman is set to start on Wednesday after a solid performance in his last game. He has had mixed success against the Cubs in the past, but the current lineup has had some success hitting against him.

Blue Jays Set to Challenge Cade Horton's Streak Against Cubs

The Blue Jays are favored to break Cade Horton's impressive streak. Toronto has been particularly dominant against right-handed pitchers in recent days, boasting a 1.011 OPS and 178 wRC+ in 226 plate appearances. Horton faces a tough challenge in this matchup, especially after pitching 22.2 consecutive scoreless innings. It is likely that he will give up a few runs in Toronto. The Cubs have struggled to hit right-handed pitchers this month, with a .642 OPS and 80 wRC+. Kevin Gausman, who has allowed one run or less in three of his last four starts, is expected to provide the Blue Jays with a solid opportunity for success.

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