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  1. Home
  2. MLB Picks
  3. St. Louis Cardinals vs San Diego Padres
Fri 9:40 PM ET
St. Louis Cardinals logo
St. Louis
Cardinals1
M. Liberatore LHP
versus
San Diego Padres logo
San Diego
Padres4
N. Pivetta RHP
Final
Team123456789T
St. Louis Cardinals0000100001
San Diego Padres000040

St. Louis Cardinals vs San Diego Padres Betting Picks & Predictions

Game time: August 1, 2025 at 9:40 PM ET

Venue: Petco Park — San Diego, California

Article updated Aug 1, 11:45 PM EDT

Published by SportsJaw Editorial Team

In this Cardinals at Padres prediction, the two playoff hopefuls will face off in a three-game series starting on Friday night in San Diego. The Cardinals are fighting for a

Game outlook

In this Cardinals at Padres prediction, the two playoff hopefuls will face off in a three-game series starting on Friday night in San Diego. The Cardinals are fighting for a wildcard spot despite recent struggles, while the Padres are in a strong position in the NL West and wildcard race. The series opener will feature a matchup between Cardinals' Matthew Liberatore and Padres' Nick Pivetta. The game is scheduled for 9:40 PM EST. Check out more details and tips in this Cardinals/Padres prediction to help maximize your bankroll.

Betting Odds

Moneyline: Cardinals +174 | Padres -200

Spread: Cardinals +1.5 (-126) | Padres -1.5 (+108)

Total: Over/Under 7.5 (-110)

Based on the moneyline, the implied probability that San Diego will win straight-up is 67%.

St. Louis Cardinals

The St. Louis Cardinals are currently in a tight race for a National League wildcard spot, but have been struggling recently, losing four of their last five games. Despite a strong performance from starting pitcher Miles Mikolas in their recent series against the Marlins, the team was shut out in the final two games. With an overall record of 55-55 and 10 games behind the division leader, the Cardinals are already looking towards next year with trade deadline moves focusing on prospects. In their upcoming series, Matthew Liberatore will be the starting pitcher with a record of 6-8 and an ERA of 4.04. The Cardinals have won three of Liberatore's last five starts, but are facing key injuries to SP Drew Rom, RP John King, and RP Zack Thompson.

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MLB · St. Louis Cardinals at San Diego Padres

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San Diego Padres

The San Diego Padres made aggressive moves at the trade deadline in hopes of securing their first World Series title in franchise history. Acquiring key arms such as JP Sears and Mason Miller from the Athletics, the Padres aim to strengthen their rotation and bullpen. Currently on a five-game winning streak, including a recent sweep of the Mets, the Padres have a record of 60-49 and are just three games behind the first-place Dodgers in the NL West Division. Righty Nick Pivetta, with a stellar 10-3 record and impressive stats, will be starting for the Padres against the Cardinals. Although facing some key injuries, the Padres remain determined and focused on their goal.

San Diego Padres Poised for Success Against St. Louis Cardinals - Place Your Wager Now!

The San Diego Padres are currently demonstrating strong performance in the MLB, closely trailing the Los Angeles Dodgers as the season enters its final stretch. Pitcher Nick Pivetta will lead the team against the St. Louis Cardinals, seeking redemption after a previous loss to the same team. Pivetta has displayed impressive prowess in home games, boasting a flawless 6-0 record in 11 starts with an exceptional ERA of 2.07. On the other hand, Cardinals pitcher Liberatore suffered defeat at the hands of the Padres in his recent outing, lasting only 4.1 innings. The Padres have reinforced their bullpen and maintained a commendable defensive record of allowing an average of two runs per game over the past ten games. With these factors in consideration, the Padres are poised for success in their upcoming match against the Cardinals on Friday. It is advisable to confidently place a wager on the Padres to secure a victory.

SportsJawGame Predictions
Predicted score

Unavailable for this preview

Projected winnerUnavailableConfidencelow
Pick on the Spread

Published pick: Unavailable

Pick on the Total

Published pick: Unavailable

#StLouisCardinals#SanDiegoPadres

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Written by

SportsJaw Editorial Team

SportsJaw published this archived preview from its original game-day article. Its prediction and quoted lines are preserved as written.

About our editorial process

SportsJaw Cardinals vs Padres archived game preview contains historical odds and availability that may no longer be current. View history of past Cardinals vs Padres matchups or learn how our predictions work.

Current matchup data

Lines, trends and availability

Line movement since open

  • Moneyline · St. Louis Cardinals+131 → +160Moved
  • Moneyline · San Diego Padres-150 → -185Moved
  • Spread · St. Louis Cardinals+1.5 (-170) → +1.5 (-120)Moved
  • Spread · San Diego Padres-1.5 (+148) → -1.5 (+104)Moved
  • Total · Over7.5 (-110) → 7.5 (-110)Unchanged
  • Total · Under7.5 (-110) → 7.5 (-110)Unchanged

ATS and O/U trends

St. Louis Cardinals
77-85 matchup record · 4-6-0 ATS · 2-6-2 O/U
Last 10 completed games on file
San Diego Padres
91-71 matchup record · 6-4-0 ATS · 3-7-0 O/U
Last 10 completed games on file

Injuries and availability

From the published research (2025-08-02T03:45:24.203Z). Availability may have changed; review the cited sources.

The St. Louis Cardinals are currently in a tight race for a National League wildcard spot, but have been struggling recently, losing four of their last five games. Despite a strong performance from starting pitcher Miles Mikolas in their recent series against the Marlins, the team was shut out in the final two games. With an overall record of 55-55 and 10 games behind the division leader, the Cardinals are already looking towards next year with trade deadline moves focusing on prospects. In their upcoming series, Matthew Liberatore will be the starting pitcher with a record of 6-8 and an ERA of 4.04. The Cardinals have won three of Liberatore's last five starts, but are facing key injuries to SP Drew Rom, RP John King, and RP Zack Thompson.

The San Diego Padres made aggressive moves at the trade deadline in hopes of securing their first World Series title in franchise history. Acquiring key arms such as JP Sears and Mason Miller from the Athletics, the Padres aim to strengthen their rotation and bullpen. Currently on a five-game winning streak, including a recent sweep of the Mets, the Padres have a record of 60-49 and are just three games behind the first-place Dodgers in the NL West Division. Righty Nick Pivetta, with a stellar 10-3 record and impressive stats, will be starting for the Padres against the Cardinals. Although facing some key injuries, the Padres remain determined and focused on their goal.

Recent head-to-head

  • 2025-07-27San Diego Padres 9 · St. Louis Cardinals 2
  • 2025-07-26San Diego Padres 3 · St. Louis Cardinals 1
  • 2025-07-25San Diego Padres 0 · St. Louis Cardinals 3
  • 2025-07-24San Diego Padres 7 · St. Louis Cardinals 9
Final result

Matchup pick recap

San Diego Padres defeated St. Louis Cardinals 4-1

San Diego Padres defeated St. Louis Cardinals 4-1 on August 1, 2025, a 3-run decision in the series. San Diego Padres' strongest period was the 5th inning, when it outscored its opponent 4-1. Against SportsJaw's recorded St. Louis Cardinals +1.5 (-120) spread, San Diego Padres covered, while the 5 combined runs finished under the recorded total of 7.5.

SportsJaw editorial picks

  • Projected winnerNo published selectionUnavailable

Tipster picks

No graded public tipster picks were recorded for this matchup.