San Francisco Giants vs
Oakland AthleticsPredictions & Preview

Oakland Athletics Favored Over San Francisco Giants in Interleague Matchup at Sutter Health Park

In the 2025 MLB season, the San Francisco Giants face off against the Athletics in an interleague series at Sutter Health Park in Sacramento, CA. The Giants previously swept a home series against the Athletics in May. The Giants vs. Athletics prediction for Friday's game sees Justin Verlander starting for the Giants and JP Sears starting for the Athletics. Oakland is the current betting favorite at -108.

Betting Odds

• Moneyline: Giants -106 | Athletics -108
• Spread: Giants -1.5 (+142) | Athletics +1.5 (-166)
• Total: Over/Under 10 (-110)
• Based on the moneyline, the implied probability that Oakland will win straight-up is 52%.

San Francisco vs Oakland Stats

San Francisco Giants

The San Francisco Giants played the Arizona Diamondbacks on Thursday night, looking to avoid a loss in a four-game series after outlasting the Diamondbacks in extra innings the previous Wednesday. The Giants have struggled recently, winning only two of their last nine games and scoring just 27 runs with a .210/.294/.340 slash line. Their bullpen has also struggled with a 5.57 ERA and a .311 batting average against. Justin Verlander is expected to pitch on Friday night with a 0-5 record, 4.26 ERA, and 1.39 WHIP so far this season. Verlander has a strong record against the Athletics in his career. The Giants are currently ranked 23rd in power rankings, with a strong defense but struggling offense.

Oakland Athletics Analysis

The Oakland Athletics suffered a 6-5 defeat against the Tampa Bay Rays on Wednesday, missing the opportunity to sweep a three-game set but still managing to win their first series in three weeks. Over their last 11 games, the A's have gone 4-7, scoring 36 runs with a .209/.287/.344 triple-slash. The bullpen has performed well with a 3.35 ERA, 1.21 WHIP, and .223 batting average against. JP Sears is predicted to start on Friday, boasting a 6-7 record with a 5.09 ERA in 17 starts this season. He recently dominated the Yankees, allowing just two hits and three walks in 5.2 scoreless innings. Sears has a 2.41 ERA in three career starts against San Francisco. The current Giants lineup has had some success against him, going 13-for-52 with a double and two home runs. The Athletics are ranked 24th in power ranking, and 20th in offense, averaging 4.15 runs per game. Their defense ranks 29th, allowing an average of 5.72 runs per game. Overall, the A's have a record of 36-53. San Francisco lost their last three matchups against Oakland.

San Francisco Giants Struggle Against Lefties, Oakland Athletics Pitching Dominates: A Preview of the Upcoming Match

The San Francisco Giants have struggled against left-handed pitchers in recent weeks, with a .173/.259/.250 slash line and 50 wRC+ in 58 plate appearances. Although they performed well against JP Sears earlier in the season, their recent performance and bullpen struggles make me hesitant to trust them in the upcoming match. On the other hand, the Oakland Athletics have shown strong pitching performances, with Sears delivering an excellent outing and the bullpen securing wins and saves. Despite the Athletics' lackluster offensive numbers against right-handed pitchers in recent weeks, their pitching strength gives them an edge in this matchup. Therefore, I am leaning towards the Oakland Athletics for this game.

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