Washington Nationals vs
Houston AstrosPredictions & Preview

Washington Nationals Poised to Upset Houston Astros in Interleague Matchup at Daikin Park

On Tuesday, July 29, 2025, the Washington Nationals will be facing the Houston Astros in an interleague match at Daikin Park in Houston, Texas. This preview excludes the results of Monday's game and provides insight into the upcoming matchup. The first pitch is set for 8:10 PM ET, with the Astros favored to win with a -145 moneyline and a total of 8.5 runs. For more information on this Nationals vs. Astros prediction and other MLB picks for Tuesday's games, please continue reading.

Betting Odds

• Moneyline: Nationals +105 | Astros -116
• Spread: Nationals +1.5 (-195) | Astros -1.5 (+170)
• Total: Over/Under 8.5 (-110)
• Based on the moneyline, the implied probability that Houston will win straight-up is 54%.

Washington Nationals

The Washington Nationals have demonstrated strong performance since the All-Star break, bouncing back from a home series loss to the San Diego Padres by winning consecutive series against the Cincinnati Reds and Minnesota Twins. Over a nine-game span, the Nationals have scored 39 runs with a .247/.309/.397 slash line. The bullpen has performed decently, with a 3.28 ERA, 1.32 WHIP, and .254 batting average against in 35.2 innings. Michael Soroka is set to pitch for the Nationals on Tuesday night at Daikin Park. With a 3-8 record, 4.85 ERA, and 1.13 WHIP in 15 starts this season, Soroka has shown solid performance in recent games despite not securing wins. In a previous matchup against the Astros in 2024, Soroka delivered a scoreless relief inning. Five Astros players have faced Soroka before, resulting in a total of three singles and a triple in 17 at-bats.

Houston Astros

The Houston Astros have had a mixed performance in the second half of the season, losing a series to the Seattle Mariners, sweeping the Arizona Diamondbacks, and then getting swept by the Athletics. During this 10-game stretch, they have scored 38 runs with a .241/.309/.345 slash line and six home runs. The bullpen has also struggled, with a 4.42 ERA, 1.42 WHIP, and .240 batting average against in 38.2 innings. Due to multiple injuries, the starting lineup for Tuesday's game is uncertain, with eight starting pitchers currently on the injured list. The Astros are currently leading the AL West by four games, despite missing key players such as Isaac Paredes, Jeremy Pena, and Yordan Alvarez.

Washington Nationals Favored in Upcoming Game Against Houston Astros Due to Key Factors

The Washington Nationals appear to be an attractive choice in this upcoming game based on several key factors. Despite Michael Soroka's recent strong pitching performances, his team has not provided adequate run support. Additionally, the Nationals will be facing the Houston Astros, who are dealing with injuries that have weakened their pitching staff. Considering these circumstances, Washington presents a promising opportunity, particularly given the favorable odds. Statistical analysis further supports this conclusion, as the Nationals have demonstrated greater success against right-handed pitchers post-All-Star break compared to the Astros. Both teams have faced challenges when hitting against left-handed pitchers in recent games. Ultimately, the combination of these elements suggests that the Nationals offer a prudent selection for this matchup.

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