Boston Red Sox vs
Philadelphia PhilliesPredictions & Preview

Red Sox Look to Even the Score Against Phillies in Interleague Showdown

The Boston Red Sox will face the Philadelphia Phillies in an interleague showdown at Citizens Bank Park on Wednesday, July 23, 2025. This game will conclude their three-game regular-season series, with the Phillies winning the opener 3-2. Our Red Sox vs. Phillies prediction and MLB picks for Wednesday's game are provided in this preview. The first pitch is scheduled for 7:00 PM ET, with the Phillies favored at -154 on the moneyline and a total of 8.5 runs. Please note that this preview was written before Tuesday's results. Thank you.

Betting Odds

• Moneyline: Red Sox +130 | Phillies -151
• Spread: Red Sox +1.5 (-165) | Phillies -1.5 (+140)
• Total: Over/Under 8.5 (-110)
• Based on the moneyline, the implied probability that Philadelphia will win straight-up is 60%.

Boston Red Sox

The Boston Red Sox have struggled in the second half of the season, losing three out of their first four games and only scoring three runs in those defeats. Despite outhitting Philadelphia in a recent game, the Red Sox struggled with runners in scoring position. Currently holding the bottom wild card spot in the American League, the Red Sox rank fifth in the MLB in runs scored and 19th in runs allowed. In July, they have a .276/.331/.474 slash line with 42 doubles, three triples, and 20 home runs. Lucas Giolito will pitch against Philadelphia, boasting a 6-2 record with a 3.59 ERA this season. In his last start, he allowed four earned runs in 5.1 innings. Giolito has a 1-1 record with a 3.86 ERA in two career starts against Philadelphia, with the current Phillies lineup having success against him in the past.

Philadelphia Phillies

The Philadelphia Phillies have had a mixed performance since the All-Star break, going 2-2 with 19 runs scored and 21 runs allowed. They secured a win against the Red Sox last Monday in extra innings, with catcher's interference playing a key role. Max Lazar earned his first major-league win in that game. The Phillies are currently leading the NL East by half a game over the New York Mets. They rank 12th in the league in runs scored and sixth in runs allowed, with a .253 batting average in July. Jesus Luzardo will pitch on Wednesday night, with an 8-5 record and 4.29 ERA in 2025. He had a solid performance against the Red Sox in 2023.

Red Sox Demonstrating Strong Performance Against Left-Handed Pitchers, Optimism for Upcoming Game against Phillies

The Boston Red Sox have demonstrated strong performance against left-handed pitchers this month, with a .772 OPS, .207 ISO, and 109 wRC+. Given this data, there is reason to be optimistic about their chances in the upcoming game. On the other hand, Jesus Luzardo has shown inconsistency recently, giving up four or more earned runs in five of his last nine starts. Meanwhile, Lucas Giolito experienced difficulties in his last outing, but has impressive stats with a 1.43 ERA and 2.84 FIP in his previous seven starts. The Philadelphia Phillies have posted a .712 OPS, .149 ISO, and 97 wRC+ against right-handed pitchers in July, which could work in Giolito's favor. Both teams' bullpens have been performing well, leading to what is expected to be a closely contested matchup. However, it should be noted that Boston's runline odds are currently unappealing.

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