San Diego Padres vs
San Francisco GiantsPredictions & Preview

Padres vs Giants: Giants Looking to Secure Series Win as Favorites against Padres

On Thursday, the San Diego Padres (35-25) will finish their four-game series against the San Francisco Giants (34-28) at Oracle Park. Despite winning the first two games in extra innings, the Padres lost 6-5 in Wednesday night's game. Dylan Cease (ERA: 4.66) will be the starting pitcher for the Padres, while Robbie Ray (ERA: 2.43) will be starting for the Giants. San Francisco is the betting favorite with the current line at -112, opening at -115. Stay tuned for our Giants vs Padres prediction.

Betting Odds

• Moneyline: Padres -101 | Giants -112
• Spread: Padres +1.5 (-213) | Giants -1.5 (+180)
• Total: Over/Under 7.5 (-110)
• Based on the moneyline, the implied probability that San Francisco will win straight-up is 53%.

San Diego vs San Francisco Stats

San Diego Padres

The San Diego Padres are aiming to secure a series win with a victory in Thursday's game, despite facing a loss in the previous match. Presently holding the second-best record in the NL West, the Padres' offense is performing well, with Manny Machado leading in batting average and Fernando Tatis Jr. excelling in both home runs and stolen bases. Gavin Sheets has also been impressive with his performance this season. The team has faced challenges in their pitching rotation due to injuries, but Nick Pivetta has been having a standout year, supported by a strong bullpen. Thursday's starting pitcher, Dylan Cease, has struggled with consistency, particularly on the road. With a power ranking of 28, the Padres rank 18th in offense, 10th in defense, and currently hold a 35-25 season record.

San Francisco Giants Analysis

The San Francisco Giants have had a remarkable turnaround in the 2025 season under the leadership of President of Baseball Operations, Buster Posey. The team has surged back into playoff contention, sitting just 3.5 games out of first place in the NL West. A major factor in their success has been their dominant bullpen, boasting the best ERA in the majors at 2.38. Left-hander Erik Miller has been exceptional with a 1.35 ERA and a 2-0 record in 24 appearances. Offensively, the team has been led by Heliot Ramos in batting average and home runs, while Wilmer Flores leads in RBI. Lefty Robbie Ray, with a 7-1 record and 2.43 ERA, is set to take the mound for the upcoming game, showcasing the team's strong pitching. The Giants currently have a power ranking of 11 and rank #20 for offense, #4 for defense, and hold an overall record of 34-28. In their recent matchups, San Diego went 1-2 against San Francisco.

Robbie Ray's Stellar Home ERA Gives Giants an Edge in Matchup Against Padres

The two teams competing in this matchup have demonstrated a closely matched level of skill, as evidenced by each of the preceding three games being decided by a slim margin of one run. A notable advantage in this particular game lies with Robbie Ray, who boasts an impressive home ERA of 1.89, resulting in the Giants securing victory in 5 out of 6 such games. Conversely, Dylan Cease carries a less impressive road ERA of 5.68, which has contributed to the Padres suffering defeats in two out of his last three starts. Considering the exceptional performance of the Giants' bullpen, I am inclined to favor Ray and his team in this forthcoming contest.

Sources: [ 1 ] [ 2 ]