San Francisco Giants vs
Chicago White SoxPredictions & Preview

Giants Favored to Win Against White Sox in Interleague Matchup at Rate Field

On June 27, 2025, the San Francisco Giants will face off against the Chicago White Sox at Rate Field in Chicago, Illinois. The Giants are favored to win with a -165 moneyline and a total of 8.5 runs. Last year, the Giants won two out of three home games against the White Sox. The starting pitchers will be Landen Roupp for the Giants and Aaron Civale for the White Sox. The game is set to start at 7:40 PM ET. The current line is in favor of San Francisco at -150. Stay informed with our Giants vs. White Sox prediction and other MLB picks for Friday's games.

Betting Odds

• Moneyline: Giants -150 | White Sox +133
• Spread: Giants -1.5 (+110) | White Sox +1.5 (-130)
• Total: Over/Under 9 (-110)
• Based on the moneyline, the implied probability that San Francisco will win straight-up is 60%.

San Francisco vs Chicago Stats

San Francisco Giants

The San Francisco Giants are hosting the Miami Marlins in a three-game series, hoping to avoid a sweep after dropping the first two games. The Giants have struggled recently, losing seven of their last 10 games and experiencing issues with their offense and bullpen. Landen Roupp is set to pitch on Friday night, with a solid 5-5 record and 3.67 ERA this season. Despite not facing the White Sox before, Roupp has a strong history in interleague play. The Giants are ranked 15th in power rankings, excelling defensively but struggling offensively, with a 44-37 record this season.

Chicago White Sox Analysis

The Chicago White Sox recently secured a much-needed victory against the Arizona Diamondbacks, led by 2B Lenyn Sosa's impressive performance. Despite some recent struggles, the White Sox have shown promise in certain areas, such as their bullpen. Pitcher Aaron Civale is set to take the mound in an upcoming game against San Francisco, where he has previously found success. The White Sox currently have a power ranking of 29 and are ranked 28th for offense and 21st for defense. The team's overall record stands at 26-55. In their last three matchups against San Francisco, the Giants came out on top in two out of three games.

Despite Civale's Past Success, Giants Favored at Runline Against White Sox

Despite Aaron Civale's positive track record against the Giants, the prudent choice would be to favor San Francisco at the runline. Civale's recent struggles, contrasted with Landen Roupp's strong performance against Boston, make the Giants a more promising pick. Although Roupp faced difficulties against the Dodgers on June 14, his overall season performance has been steady. Additionally, the White Sox have had difficulty hitting right-handed pitchers in recent days, which could work in favor of the Giants. While the Giants' recent statistics against righties are not exceptional, their lineup boasts several potent hitters who could impact the game. Taking these factors into consideration, the Giants may have the potential to secure a victory in this match-up.

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