Chicago White Sox vs
Houston AstrosPredictions & Preview

White Sox to take on Astros in American League showdown at Daikin Park

The Chicago White Sox will face off against the Houston Astros in an American League showdown on Wednesday, June 11 at Daikin Park in Houston, TX. This game is part of a three-game series between the two teams, with the White Sox having won their previous matchup last month. The Astros are currently the favorites with a moneyline of -180 and a total of 8.5 runs. The starting pitchers for the game will be Sean Burke for the White Sox and Ryan Gusto for the Astros. Houston opened as the favorite at -175 and the line has not moved. For more information on this game and other MLB picks for Wednesday, be sure to stay updated. The first pitch is scheduled for 8:10 PM ET.

Betting Odds

• Moneyline: White Sox +158 | Astros -175
• Spread: White Sox +1.5 (-137) | Astros -1.5 (+114)
• Total: Over/Under 8 (-110)
• Based on the moneyline, the implied probability that Houston will win straight-up is 64%.

Chicago vs Houston Stats

Chicago White Sox

In June, the Chicago White Sox faced a defeat at the Baltimore Orioles, extending their losing streak to four games. However, they managed to split a series against the Detroit Tigers and win two out of three games against the Kansas City Royals during a seven-game homestand. Currently, the White Sox rank last in the American League, with their offense scoring an average of 3.53 runs per game and their defense allowing 4.30 runs per game. Sean Burke will be pitching on Wednesday night with a record of 3-6 and a 4.03 ERA this season. Despite his previous success in May, Burke has not faced the Astros before and will be relying on his five-pitch arsenal to secure a win. Chicago is currently ranked 26th in offense and 19th in defense, with an overall record of 22-44 this season.

Houston Astros Analysis

The Houston Astros have been on an impressive winning streak, remaining undefeated in five consecutive series. They have secured victories against the Seattle Mariners, Pittsburgh Pirates, Cleveland Guardians, and Oakland Athletics, and split a series with the Tampa Bay Rays. Currently, the Astros are leading the AL West division by three games. Their offense ranks 23rd in the MLB, scoring an average of 4.02 runs per game, while their defense ranks 6th, allowing an average of 3.66 runs per game. Ryan Gusto is set to start on Wednesday, carrying a 3-3 record with a 4.78 ERA in the 2025 season. Despite a recent loss, Gusto will look to bounce back against the upcoming opponent. The Astros have a power ranking of 18 and hold a 36-29 overall record. The Chicago White Sox recently went 1-2 against the Astros in their last three matchups.

White Sox Expected to Challenge Astros Despite Pitching Struggles

Ryan Gusto had a strong performance in April with a 3.24 ERA in 25 innings pitched, but faced challenges in May with an 8.25 ERA in 12 innings. Despite his recent struggles, Gusto has posted a 5.11 ERA and 5.26 FIP in his last three starts. I believe the White Sox have the potential to keep this game close and surpass the runline. Sean Burke has demonstrated consistent performance recently, particularly against the Astros who have a low slash line of .193/.244/.287 with a 51 wRC+ against right-handed pitchers in June. The White Sox have shown competence with a .236/.321/.355 triple-slash and a 91 wRC+ facing right-handed pitchers this month. While the Astros bullpen is known for its strength, the White Sox bullpen has shown promise this month with a 2-2 record, save, and a 3.97 ERA.

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