Houston Astros vs
Chicago White SoxPredictions & Preview

Astros' Lance McCullers Jr. returns to the mound to lead team against White Sox in series finale with favorable odds at -210

The Astros are looking to bounce back in the series finale against the White Sox, with Lance McCullers Jr. making his return to the mound after two seasons out with arm issues. The pitching matchup will see McCullers facing off against Bryse Wilson. The Astros are the favorites with a -210 opening line. Catch the game at 2:10 PM EST and check out our top picks to enhance your betting experience.

Betting Odds

• Moneyline: Astros -210 | White Sox +180
• Spread: Astros -1.5 (-130) | White Sox +1.5 (+110)
• Total: Over/Under 8.5 (-110)
• Based on the moneyline, the implied probability that Houston will win straight-up is 68%.

Houston vs Chicago Stats

Houston Astros

The Houston Astros are looking to find their consistency in the 2025 season after a strong start followed by some recent setbacks. Despite dropping their last two games, they bounced back with a dominant 8-3 win against the White Sox, led by offensive standout Jake Myers and solid pitching from Hunter Brown. Lance McCullars will make his first start in two seasons in the series finale. Currently ranked 21st in offense, 5th in defense, and sitting at a record of 16-15, the Astros are focused on integrating McCullars back into the rotation and continuing their success on the field.

Chicago White Sox Analysis

The Chicago White Sox have continued to struggle in the 2025 season, with only nine wins so far. After a tough loss to the Astros, the team will be relying on Bryse Wilson in a bullpen game on Sunday. Wilson has a record of 0-1 with an ERA of 5.00. The White Sox have key injuries impacting their lineup. Currently, the team has a power ranking of 25, ranking 25th in offense and 14th in defense. Overall, the team is 9-23 for the season. Houston won 1 out of the last 3 matchups against Chicago.

Astros poised for victory against struggling White Sox with strong pitching and offense

The Houston Astros are seeking consistency in their performance and are poised to secure a win in this upcoming matchup. The Chicago White Sox will be utilizing a bullpen strategy on Sunday, which is expected to benefit the Astros' offense. The Astros will be entrusting Lance McCullers for the first time in over two years, with confidence in his abilities. In contrast, the White Sox have struggled with a team batting average of .216 and a poor daytime record of 7-13 this season. On the other hand, the Astros have maintained a .240 team batting average and a decent 5-5 daytime record leading up to Saturday's game. It is anticipated that the Astros will come out strong on Sunday and dominate the White Sox early in the game. Therefore, it is advisable to take the Astros with the money line.

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