St. Louis Cardinals vs
Baltimore OriolesPredictions & Preview

Orioles Favored Against Cardinals in Wednesday Matchup at Camden Yards

The 2025 MLB betting action on Wednesday, May 28 features the St. Louis Cardinals facing off against the Baltimore Orioles at Oriole Park at Camden Yards. The Orioles won the first game of the series 5-2 and are favored at -115 for the upcoming matchup, with a totals line of 9.0 runs. Miles Mikolas will be starting for the Cardinals, while Cade Povich takes the mound for the Orioles. Baltimore opened as -120 favorites and the line remains unchanged.

Betting Odds

• Moneyline: Cardinals +109 | Orioles -120
• Spread: Cardinals -1.5 (+152) | Orioles +1.5 (-184)
• Total: Over/Under 8.5 (-110)
• Based on the moneyline, the implied probability that Baltimore will win straight-up is 55%.

St. Louis vs Baltimore Stats

St. Louis Cardinals

The St. Louis Cardinals recently ended a three-game winning streak with a loss at Camden Yards, where they only mustered four hits and their defense committed costly turnovers. Despite this setback, the Cardinals have shown improvement this month and are now considered playoff contenders. They rank 8th in the MLB in runs scored and 12th in runs allowed. Pitcher Miles Mikolas has been a key player, with a solid record and favorable stats. The team's power ranking is 1, ranked 8th in offense and 12th in defense, with a season record of 30-24.

Baltimore Orioles Analysis

The Baltimore Orioles recently extended their winning streak to three games with a victory over St. Louis, outscoring them 10-4. Despite this recent success, the Orioles hold the second-worst record in the American League at 19-34. They struggle offensively, ranking 26th in the majors in runs scored and 28th in runs allowed. Cade Povich is set to pitch for the Orioles in their upcoming game, with a record of 1-3 and a 4.86 ERA this season. The Orioles have a power ranking of 28 and rank 25th for offense and 28th for defense, with St. Louis going 1-2 in their last three matchups against Baltimore.

Cardinals Offense Falters Against Left-Handed Pitchers, Orioles Favored in Upcoming Game

Recently, the Cardinals' offensive performance has shown a decline, especially against left-handed pitchers in the past 10 days with a .556 OPS and 56 wRC+ in 82 plate appearances. As a result, I am favoring the Orioles in the upcoming game. While Cade Povich may not inspire complete confidence, he has displayed solidity in his last two starts, and the Cardinals have not faced him previously. On the contrary, Miles Mikolas aims to continue his impressive form. Nonetheless, the Orioles have been effective against right-handed pitchers in the last 10 days, recording a .734 OPS and 110 wRC+. With a struggling pitching staff, the Orioles must rely on their offense. Povich's performance will be crucial in determining the outcome of Wednesday night’s game.

Sources: [ 1 ] [ 2 ]