Los Angeles Dodgers vs
Cleveland GuardiansPredictions & Preview

Dodgers Look to Continue Dominance Over Guardians in Series Opener on Memorial Day

The 2025 Major League Baseball season continues with a 12-game slate on Memorial Day, featuring an interleague battle between the Los Angeles Dodgers and the Cleveland Guardians at Progressive Field in Cleveland, OH. The Dodgers, who took two out of three games from the Guardians last season, will aim for their third straight victory over Cleveland in this three-game series opener. The first pitch is scheduled for 6:10 PM ET. Yoshinobu Yamamoto (ERA: 1.86) will start for the Dodgers, while Gavin Williams (ERA: 3.94) will take the mound for the Guardians. Los Angeles is the betting favorite with an opening line of -175 that has not moved. Stay tuned for more MLB picks for Monday, May 26.

Betting Odds

• Moneyline: Dodgers -175 | Guardians +158
• Spread: Dodgers -1.5 (-110) | Guardians +1.5 (-110)
• Total: Over/Under 8 (-110)
• Based on the moneyline, the implied probability that Los Angeles will win straight-up is 64%.

Los Angeles vs Cleveland Stats

Los Angeles Dodgers

The Los Angeles Dodgers faced off against the New York Mets in a rubber match at Citi Field, hoping to bounce back from a recent defeat. Despite winning three games in a row, the Dodgers have struggled in their last eight games, particularly with their pitching staff allowing 46 runs. Yoshinobu Yamamoto, their top pitcher, is expected to start on Memorial Day with impressive stats this season. The Dodgers have a strong offense but have been lacking defensively, ranking second in offense and 22nd in defense. With a record of 32-20 this season, the Dodgers are positioned well in the league.

Cleveland Guardians Analysis

The Cleveland Guardians suffered a 5-0 defeat against the Detroit Tigers, ending their four-game winning streak and missing a chance to sweep a four-game road series. They have gone 4-6 in their last 10 games, scoring 38 runs while yielding 39 runs. The bullpen has a 4.11 ERA in 30.2 innings of work. Gavin Williams is projected to start the next game with a 4-2 record and a 3.94 ERA. He had a strong performance in his last outing against the Twins. However, he has struggled in two career starts against the Dodgers. The Guardians have a power ranking of 20 and rank 23rd in offense, 15th in defense, and currently have a 29-21 overall record. Los Angeles went 1-2 in their last three matchups against Cleveland.

Dodgers Favored in Matchup Against Guardians Due to Strong Pitching Performance

Gavin Williams has been impressive in his recent starts, maintaining a 2.25 ERA in May while consistently limiting runs. However, his track record against the Dodgers is concerning, with the current lineup having success against him. On the other hand, Yoshinobu Yamamoto has shown strong performance, particularly on the road, with only one subpar start this season and a 1.86 ERA in those games. Considering the Guardians' recent struggles against right-handed pitchers and the Dodgers' strong offensive numbers against righties, Yamamoto appears to have the advantage in this matchup. As a result, the Dodgers seem like a more favorable choice for this game based on their performance and the pitching matchup.

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