San Diego Padres vs
Toronto Blue JaysPredictions & Preview

Toronto Blue Jays Favored to Beat San Diego Padres in MLB Matchup at Rogers Centre

On Wednesday, May 21, the San Diego Padres will face off against the Toronto Blue Jays at Rogers Centre in Toronto, ON during the 2025 Major League Baseball season. The Padres vs. Blue Jays prediction and latest odds update indicate that Randy Vasquez will be starting for the Padres with an ERA of 3.45, while Kevin Gausman will be starting for the Blue Jays with an ERA of 4.59. Toronto is the betting favorite opening at -149 with the current line at Toronto -157. The game is set to start at 7:07 PM ET as part of a three-game series at Rogers Centre.

Betting Odds

• Moneyline: Padres +139 | Blue Jays -157
• Spread: Padres +1.5 (-150) | Blue Jays -1.5 (+130)
• Total: Over/Under 8.5 (-110)
• Based on the moneyline, the implied probability that Toronto will win straight-up is 61%.

San Diego vs Toronto Stats

San Diego Padres

The San Diego Padres, with a record of 27-19, are looking to bounce back from a three-game losing streak. Despite ranking 13th in offense and 6th in defense, the team has struggled with their bullpen in recent games. Pitcher Randy Vasquez will take the mound in their upcoming game against the Blue Jays, hoping to improve on his season stats and a previous loss to the team.

Toronto Blue Jays Analysis

The Toronto Blue Jays struggled last week, losing two out of three games in consecutive series against the Tampa Bay Rays and Detroit Tigers. The team has scored 23 runs and allowed 29 runs during this stretch. In terms of offensive performance, the Blue Jays rank 23rd in the MLB for runs scored, 22nd in slugging percentage, and tied for 14th in OPS+. On the defensive side, they allow an average of 4.50 runs per game, ranking 21st in the majors. The team's bullpen has been performing well recently with a 2.73 ERA and 0.79 WHIP over the last 10 days. Pitcher Kevin Gausman will be starting the next game, coming off a tough outing where he gave up six earned runs in 5.2 innings against the Rays. Gausman has a 3-4 record with a 4.59 ERA this season. The Blue Jays have a power ranking of 19 and currently sit at 23-24 overall. In their last meeting, San Diego won two out of three games against Toronto.

Blue Jays Favored to Win Game Despite Padres' Historical Success Against Gausman

I will be selecting the Blue Jays to prevail in the upcoming game, despite the Padres' strong historical record against Kevin Gausman, who has been struggling this season. While Randy Vasquez has shown promise in his previous starts, his expected ERA and walk percentage raise concerns. Both teams have had success against right-handed pitchers recently, with the Blue Jays slightly outperforming the Padres. Additionally, I anticipate the Blue Jays to have an advantage in the bullpen, as Toronto's relief pitching has been performing well compared to the struggling Padres bullpen, which recently allowed five earned runs on eight hits and eight walks in the Mariners series.

Sources: [ 2 ] [ 3 ]