Oakland Athletics vs
San Francisco GiantsPredictions & Preview

Giants Favored to Win in Pitching Duel Against Athletics in Interleague Series Opener

On Friday, May 16, the Oakland Athletics and San Francisco Giants will face off in the first game of a three-game interleague series at Oracle Park in San Francisco, CA. The Giants are favored to win with a -170 moneyline, while the total runs are set at 7.5, leaning towards the under. JP Sears will start for the Athletics with a 2.8 ERA, while Logan Webb will start for the Giants with a 2.6 ERA. The current line has San Francisco at -185. To read more about this matchup and other MLB picks for Friday's games, be sure to check out our prediction.

Betting Odds

• Moneyline: Athletics +166 | Giants -185
• Spread: Athletics +1.5 (-135) | Giants -1.5 (+118)
• Total: Over/Under 7 (-110)
• Based on the moneyline, the implied probability that San Francisco will win straight-up is 65%.

Oakland vs San Francisco Stats

Oakland Athletics

This article discusses the Oakland Athletics' recent performance in a three-game series against the Los Angeles Dodgers, where they won the first game but lost the second. The A's pitching staff has struggled this season, ranking low in ERA, runs allowed per game, and WHIP. However, the offense has been more successful, ranking in the middle of the league in runs scored per game and seventh in OPS. Pitcher JP Sears is expected to start the next game against the Giants after performing well in previous outings. The article also provides statistics on Sears' performance against the Giants in past matchups. Overall, the Oakland Athletics are ranked 19th in power ranking, with a strong offense but weak defense.

San Francisco Giants Analysis

The San Francisco Giants have faced recent challenges, including losses to the Minnesota Twins and Arizona Diamondbacks. Despite their struggles, the Giants' bullpen has maintained strong numbers, with a 2.68 ERA and .204 batting average against. At the plate, they have a .237/.312/.386 slash line and score an average of 4.75 runs per game. Pitcher Logan Webb has been performing well, with a 2.60 ERA and 1.16 WHIP in nine starts this season. Going into their upcoming game against the Athletics, Webb has a history of success against them, including a complete-game shutout in their last meeting. The Giants currently have a power ranking of 16 and are ranked 9th in offense and 8th in defense in the MLB. Despite their recent losses, they hold a record of 25-19. The Oakland Athletics have won two out of their last three matchups against the Giants.

Pitching Duel Expected as San Francisco Giants Face Off Against Oakland Athletics

In recent games, the San Francisco Giants have demonstrated competence against left-handed pitchers, achieving a 102 Weighted Runs Created Plus (wRC+) and a .258/.320/.409 triple-slash line in 75 plate appearances. Conversely, the Oakland Athletics have excelled against right-handed pitchers with a 125 wRC+ and a .284/.343/.462 triple-slash line during the same period. While the Athletics may present a more potent offensive threat, they have historically struggled against Logan Webb, who has had only one poor performance in the 2025 season. The upcoming matchup between Webb and JP Sears promises to be a compelling pitching duel, with both lineups likely to face challenges in the early innings. Anticipated contributions from the Giants’ bullpen, which has maintained a 3.31 ERA in the last 10 days, may prove pivotal, particularly considering the struggles of the Athletics’ bullpen which has posted an 8.70 ERA during the same timeframe.

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