Cincinnati Reds vs
Houston AstrosPredictions & Preview

Houston Astros Favored to Win Against Cincinnati Reds in Saturday Matchup at Daikin Park

The 2025 Major League Baseball season is set to continue with a game between the Cincinnati Reds and Houston Astros at Daikin Park on Saturday, May 10. The Astros are favored to win with a moneyline of -130 and a total of 8.0 runs for the game. Brady Singer will be the starting pitcher for the Reds, while Lance McCullers Jr. will be starting for the Astros. The first pitch is scheduled for 7:10 PM ET. Be sure to read more about this Reds vs. Astros prediction and check out all of our MLB picks for Saturday's games.

Betting Odds

• Moneyline: Reds +117 | Astros -129
• Spread: Reds +1.5 (-200) | Astros -1.5 (+164)
• Total: Over/Under 8 (-110)
• Based on the moneyline, the implied probability that Houston will win straight-up is 56%.

Cincinnati vs Houston Stats

Cincinnati Reds

Over the past few series, the Cincinnati Reds have struggled both on the field and at the plate, losing consecutive series against Washington and Atlanta. They have been particularly weak at the plate, with a .205/.288/.311 slash line over the last 10 days. The bullpen has posted a 3.95 ERA during this period. Looking ahead, Brady Singer will be pitching at Daikin Park on Saturday with a record of 4-2 and a 3.66 ERA for the season. Against Houston, Singer has a career record of 1-2 with a 4.23 ERA in five starts. The Reds are currently ranked 10th in offense, 11th in defense, and are 19-20 this season with a power ranking of 9.

Houston Astros Analysis

The Houston Astros have displayed inconsistency this season, going 5-5 in their last 10 games and dropping consecutive three-game road series. Despite scoring 53 runs and posting solid offensive numbers, their bullpen has a 3.55 ERA in the same span. Lance McCullers Jr. is set to start on Saturday after a strong season debut. The Astros currently have a power ranking of 16 and are ranked #18 for offense, averaging 4.03 runs per game. Their defense is ranked #5, giving up an average of 3.58 runs per game. They have an overall record of 18-18. The Cincinnati Reds have struggled against the Astros in their previous matchups, going 0-3.

Astros Favored Over Reds in Matchup Thanks to McCullers Jr.'s Strong Pitching

The Houston Astros are favored in the upcoming game against the Cincinnati Reds, due in part to Lance McCullers Jr.'s performance on the mound. While McCullers Jr. may not last the entire game, the Astros are confident in their bullpen to secure a victory. The Reds have struggled offensively, evidenced by their 60 wRC+ against right-handed pitchers within the last 10 days, compared to Houston's 117 wRC+. Despite missing Yordan Alvarez, the Astros' lineup remains a formidable threat. Familiarity with Brady Singer gives Houston an advantage, and they are expected to capitalize on their offensive prowess to exploit the Reds' bullpen late in the game. As a result, I predict the Astros will emerge victorious at the moneyline.

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