Chicago White Sox vs
Cleveland GuardiansPredictions & Preview

White Sox vs Guardians: Battle of Pitchers in Anticipated Matchup at Progressive Field

On Wednesday, the Chicago White Sox will be facing off against the Cleveland Guardians at Progressive Field with the first pitch scheduled for 6:10 p.m. ET. Last season, the Guardians won eight out of the 13 times they faced the White Sox, with the total split 5-5 in the last ten games. Sean Burke with an ERA of 5.23 will be the starting pitcher for the White Sox, while Logan Allen with an ERA of 6.75 will be starting for the Guardians. Cleveland is the betting favorite opening at -187 with the current line being Cleveland -188. For more information on the White Sox vs. Guardians prediction, continue reading.

Betting Odds

• Moneyline: White Sox +162 | Guardians -188
• Spread: White Sox +1.5 (-140) | Guardians -1.5 (+120)
• Total: Over/Under 7.5 (-110)
• Based on the moneyline, the implied probability that Cleveland will win straight-up is 65%.

Chicago vs Cleveland Stats

Chicago White Sox

The Chicago White Sox are currently struggling with a record of 2-7, still searching for their first series victory of the 2025 MLB season. Right-hander Sean Burke will start on Wednesday against Cleveland, with a 1-1 record and a 5.23 ERA this season. The team is ranked 22nd in offense, 11th in defense, and has a power ranking of 22. The White Sox have made some changes to their roster, including a new manager, but injuries may impact their upcoming game against the Guardians, with LF Andrew Benintendi listed as questionable.

Cleveland Guardians Analysis

Cleveland Guardians have had mixed results so far this season, with a record of 3-6. They lost two of three games to Los Angeles (AL) in their last series, were swept by San Diego in the previous series, but won two of three against Kansas City to start the season. Left-hander Logan Allen will start on Wednesday against Chicago, after allowing four runs and seven hits in his only appearance this season. The Guardians, who had the second-best record in the American League last season, made significant changes in the offseason, leaving them with a talented but volatile relief group, a lineup lacking depth, and an unproven starting rotation. Despite this, they are in the most winnable division in baseball and should be in the playoff picture come October. The team has no new injuries to report for Wednesday's game. Their power ranking is 19, ranking 15th in offense and 28th in defense. Chicago has had the upper hand in their recent matchups, winning all three games.

Expert Analysis Predicts Outcome of White Sox vs Guardians MLB Game - Who Will Win?

Gain insight on the anticipated outcome of the upcoming MLB game between the White Sox and the Guardians by exploring our expert analysis and prediction. Discover which team may emerge victorious in this highly anticipated matchup. Stay informed on the latest updates and analysis to make an informed decision on the potential winner of this game.

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