Baltimore Orioles vs
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Diamondbacks Favored to Win Interleague Clash Against Orioles in Series Finale - MLB Betting Action on Wednesday, April 9

On Wednesday, April 9, the 2025 MLB betting action includes a full 15-game card, with an interleague clash between the Orioles and Diamondbacks at Chase Field in Phoenix, AZ at 3:40 PM ET. The Orioles lead the series 1-0 after winning the opener 5-1. The starting pitchers will be Dean Kremer for the Orioles and Brandon Pfaadt for the Diamondbacks. Arizona is the betting favorite at -125 with the line unchanged. Stay tuned for the best Orioles vs. Diamondbacks prediction for this matchup.

Betting Odds

• Moneyline: Orioles +110 | Diamondbacks -125
• Spread: Orioles +1.5 (-190) | Diamondbacks -1.5 (+165)
• Total: Over/Under 9.25 (-110)
• Based on the moneyline, the implied probability that Arizona will win straight-up is 56%.

Baltimore vs Arizona Stats

Baltimore Orioles

The Baltimore Orioles secured a victory against the Diamondbacks thanks to a strong offensive showing against Zac Gallen. Ryan O'Hearn stood out with a 2-for-4 performance and a solo home run. The Orioles have been performing well offensively, ranking 11th in the majors in runs scored per game. On the defensive side, they are ranked 18th in ERA and 17th in WHIP. Dean Kremer is set to pitch the next game, with a 1-1 record and a 6.52 ERA this season. Overall, the Orioles have a power ranking of 10, ranking 11th in offense and 16th in defense, with a 5-6 record so far this season.

Arizona Diamondbacks Analysis

The Arizona Diamondbacks struggled in Monday's 5-1 loss to the Orioles, mustering just five hits. Second baseman Ketel Marte missed his third consecutive game due to a hamstring injury and is expected to be sidelined for at least a week. Marte has been a key player for the team, with a .930 OPS in his first eight games of the season. Arizona's offense was ranked fifth in the league in runs scored per game, hitting .253/.337/.431 with 12 home runs in 364 at-bats. Their pitching staff, however, ranked 26th in ERA and 14th in WHIP. Brandon Pfaadt is set to start on Wednesday, with a 1-1 record, 5.25 ERA, and 1.08 WHIP in two starts this season. Pfaadt previously faced the Orioles in 2024, resulting in a 5-4 loss. The Diamondbacks have a power ranking of 11, ranking fifth in offense and 22nd in defense, with an overall record of 5-6. The Orioles went 1-2 in their last three matchups against Arizona.

Diamondbacks Favored in Close Contest Against Orioles in Series Finale

The upcoming conclusion of this series is expected to be closely contested, with both teams having strong arms in their bullpens despite concerns about the starting duo. Notably, both teams have performed well against right-handed pitchers this season. The Diamondbacks have a history of success against Dean Kremer, with notable performances from players such as Josh Naylor and Lourdes Gurriel Jr. In contrast, the current Orioles have a more limited track record against Brandon Pfaadt. Pfaadt's previous success at Camden Yards provides some optimism for a strong performance. Given these factors, the Diamondbacks have a slight advantage going into the final game of the series.

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