Cincinnati Reds vs
San Francisco GiantsPredictions & Preview

Giants Look to Continue Dominance Over Reds in Highly Anticipated Matchup

In the upcoming opening game of a three-game series, the San Francisco Giants (8-1) will face off against the Cincinnati Reds (3-7). The Giants previously took two out of three games in the opening series against the Reds in Cincinnati earlier this season. Hunter Greene will be starting for the Reds with an ERA of 2.25, while Logan Webb will be starting for the Giants with an ERA of 3. San Francisco is the betting favorite with odds opening at -147 and the line remaining unchanged. Stay tuned to see which team comes out on top in this highly anticipated matchup.

Betting Odds

• Moneyline: Reds +127 | Giants -147
• Spread: Reds +1.5 (-178) | Giants -1.5 (+154)
• Total: Over/Under 7 (-110)
• Based on the moneyline, the implied probability that San Francisco will win straight-up is 60%.

Cincinnati vs San Francisco Stats

Cincinnati Reds

The Cincinnati Reds started the 2025 season with an over/under win total of 78.5 on DraftKings. Hunter Greene, who has a 0-1 record and a 2.25 ERA, will be starting for the Reds on Monday. In the season opener, Greene had a strong performance with eight strikeouts in five innings, but the bullpen was unable to hold on for the win. The team has struggled recently, losing five of their last six games, including an 8-2 loss to Milwaukee on Sunday. Despite starting the season 2-2 with a 14-3 win over Texas, the Reds have struggled to score runs, with two runs or less in five of their last six games. Offensively, Elly De La Cruz leads the team with 10 RBI, while Matt McLain has three home runs and five RBI. Cincinnati currently has a power ranking of 21, ranking 13th in offense and 7th in defense, and holds a 3-6 record for the season.

San Francisco Giants Analysis

The San Francisco Giants are currently on a hot streak with a seven-game winning streak, tied for first in the competitive NL West division. They have consistently scored at least four runs in seven of their nine games this season, with key players Wilmer Flores and Heliot Ramos leading the team in home runs and RBI. Logan Webb will be starting on Monday with a 1-0 record and a 3.00 ERA. The Giants have surpassed expectations for the 2025 season with an over/under win total of 80.5 on DraftKings, making them the biggest surprise team in MLB. The team has a power ranking of 18, ranking #5 for offense, #6 for defense, and an impressive 7-1 overall record. Their upcoming matchup against the Cincinnati Reds may prove to be a tough challenge, with Cincinnati winning 2 out of their last 3 matchups against San Francisco.

San Francisco Giants Dominating Over Cincinnati Reds in Current MLB Season

In the current baseball season, the San Francisco Giants have shown superior performance compared to the Cincinnati Reds. The Giants are currently ranked sixth in MLB for averaging 5.4 runs per game and are third with a team ERA of 1.75. On the other hand, the Reds have struggled offensively, averaging only 2.5 runs in their last six games. Although their ERA of 3.86 is decent, it does not measure up to the level at which the Giants are currently playing. Given these statistics, it is my professional opinion that the Giants are the stronger team in this matchup.

Sources: [ 1 ] [ 2 ]