St. Louis Cardinals vs
Pittsburgh PiratesPredictions & Preview

Cardinals vs. Pirates: NL Central Rivals Clash in Monday Night Showdown at PNC Park

On Monday, the St. Louis Cardinals will face off against the Pittsburgh Pirates at PNC Park, with first pitch scheduled for 6:40 p.m. ET. In the last season, the Cardinals emerged victorious in nine out of the 13 meetings between the two teams, with the under hitting in seven out of the last ten games. For the upcoming game, Matthew Liberatore (ERA: 4.5) will take the mound for the Cardinals, while Carmen Mlodzinski (ERA: 9.82) will start for the Pirates. St. Louis is currently the betting favorite with an opening line of -123, which has remained steady. Read on for our Cardinals vs. Pirates prediction.

Betting Odds

• Moneyline: Cardinals -123 | Pirates +108
• Spread: Cardinals -1.5 (+135) | Pirates +1.5 (-155)
• Total: Over/Under 8.5 (-110)
• Based on the moneyline, the implied probability that St. Louis will win straight-up is 55%.

St. Louis vs Pittsburgh Stats

St. Louis Cardinals

St. Louis Cardinals recently wrapped up a doubleheader against Boston due to a rainout on Saturday, and will have left-hander Matthew Liberatore on the mound for their upcoming game against Pittsburgh. Despite finishing second in the NL Central last season, the team has undergone some changes, including letting Paul Goldschmidt sign with the Yankees. While there is a youth movement in progress, the experienced pitching staff adds depth to the roster. Although not considered a rebuild year, it may be challenging for St. Louis to compete for more than a Wild Card spot this season. Currently, there are no injuries reported for Monday's game. St. Louis is ranked 2nd in offense, scoring an average of 7.29 points per game, but ranks 26th in defense, allowing an average of 5.43 points against them per game. Their current record stands at 4-3 for the season.

Pittsburgh Pirates Analysis

Pittsburgh recently concluded a three-game series with New York (AL), losing the first two games by a combined score of 19-8. The team will start righty Carmen Mlodzinski against St. Louis. In his 2025 debut, Mlodzinski gave up four runs on seven hits in a 3.2-inning loss to Tampa Bay. Pittsburgh's Paul Skenes will be a key player to watch in the 2025 season, as the team made minimal roster changes during the offseason. The Pirates will need young players to step up to improve their standing, as they currently have a record of 2-7. The team has a power ranking of 26 and ranks #27 in offense and #20 in defense. Despite a tough start to the season, Pittsburgh remains optimistic about their potential moving forward. Additionally, there are no new injuries reported for Monday's game against the Cardinals.

NL Central Rivals St. Louis Cardinals and Pittsburgh Pirates Face Off in Prediction Outcome

Discover the outcome between the NL Central adversaries, the St. Louis Cardinals and the Pittsburgh Pirates, in the following prediction.

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