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  1. Home
  2. MLB Picks
  3. St. Louis Cardinals vs Boston Red Sox
Sun 7:00 PM ET
St. Louis Cardinals logo
St. Louis
Cardinals7
M. Mikolas RHP
versus
Boston Red Sox logo
Boston
Red Sox18
H. Dobbins RHP
Final
Team123456789T
St. Louis Cardinals1001001047
Boston Red Sox15401520

St. Louis Cardinals vs Boston Red Sox Betting Picks & Predictions

Game time: April 6, 2025 at 7:00 PM ET

Venue: Fenway Park — Boston, Massachusetts

Article updated Apr 6, 6:17 AM EDT

Published by SportsJaw Editorial Team

On Sunday night, the St. Louis Cardinals will face off against the Boston Red Sox at Fenway Park in Massachusetts for the final game of their series. This game is the second

Game outlook

On Sunday night, the St. Louis Cardinals will face off against the Boston Red Sox at Fenway Park in Massachusetts for the final game of their series. This game is the second of a day-night doubleheader due to Saturday's rainout. The Red Sox currently lead the series 1-0 after winning the opener 13-9. Boston is a slight -112 favorite with a total of 9.0 runs. Miles Mikolas will be starting for the Cardinals with a 3.38 ERA, while Sean Newcomb will take the mound for the Red Sox with a 9.00 ERA. Boston opened as a -117 favorite and the line has remained steady. Check out our prediction for this matchup and all of our MLB picks for Sunday's games.

Betting Odds

Moneyline: Cardinals +105 | Red Sox -117

Spread: Cardinals -1.5 (+146) | Red Sox +1.5 (-176)

Total: Over/Under 9.5 (-110)

Based on the moneyline, the implied probability that Boston will win straight-up is 54%.

St. Louis Cardinals

The St. Louis Cardinals recently avoided a sweep by beating the Los Angeles Angels 12-5 and then faced a tough loss at Fenway Park despite a strong offensive performance. The team's offense has been exceptional, averaging 7.29 runs per game and boasting impressive stats. Miles Mikolas is set to pitch on Sunday, with a good track record against Boston. The Cardinals are currently ranked 5th in power rankings, 2nd in offense, 15th in defense, and hold a 77-85 record this season.

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18
MLB · St. Louis Cardinals at Boston Red Sox

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Boston Red Sox Analysis

The Boston Red Sox are currently on a three-game winning streak after defeating the Cardinals 13-9 on Friday. Trevor Story's three-run homer in the first inning helped lead the team to victory. So far this season, the Red Sox have scored a total of 40 runs and have a batting average of .256/.335/.415. The pitching staff has recorded a 4.24 ERA, 3.64 FIP, and 1.25 WHIP. Sean Newcomb will be pitching on Sunday and will be looking to bounce back from a rough outing in his season debut. Despite a challenging history against the Cardinals, Newcomb will be aiming for a better performance. The Red Sox currently have a power ranking of 14 and are ranked #15 for offense, #10 for defense, with an overall record of 87-75. St. Louis has won two out of their last three matchups against Boston.

Red Sox Face Tough Matchup Against Cardinals Amidst Pitching Injuries

Due to injuries to Brayan Bello and Lucas Giolito, the Red Sox are utilizing Sean Newcomb in their starting rotation. However, Newcomb may face challenges in the upcoming matchup, as the Cardinals have displayed impressive offensive statistics against left-handed pitchers this season, boasting a .910 OPS and 157 wRC+. Nolan Arenado, in particular, has had success against Newcomb, going 7-for-15 with two home runs. Additionally, the current Red Sox lineup has struggled against Miles Mikolas, with only a 6-for-31 record and minimal extra-base hits. Considering these factors, it appears favorable to favor the Cardinals in this game.

SportsJawGame Predictions
Predicted score

Unavailable for this preview

Projected winnerUnavailableConfidencelow
Pick on the Spread

Published pick: Unavailable

Pick on the Total

Published pick: Unavailable

#StLouisCardinals#BostonRedSox

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Written by

SportsJaw Editorial Team

SportsJaw published this archived preview from its original game-day article. Its prediction and quoted lines are preserved as written.

About our editorial process

SportsJaw Cardinals vs Red Sox archived game preview contains historical odds and availability that may no longer be current. View history of past Cardinals vs Red Sox matchups or learn how our predictions work.

Current matchup data

Lines, trends and availability

Line movement since open

  • Moneyline · St. Louis Cardinals+105 → +110Moved
  • Moneyline · Boston Red Sox-117 → -122Moved
  • Spread · St. Louis Cardinals-1.5 (+146) → +1.5 (-175)Moved
  • Spread · Boston Red Sox+1.5 (-176) → -1.5 (+150)Moved
  • Total · Over9.5 (-110) → 9.5 (-110)Unchanged
  • Total · Under9.5 (-110) → 9.5 (-110)Unchanged

ATS and O/U trends

St. Louis Cardinals
77-85 matchup record · 7-3-0 ATS · 7-2-1 O/U
Last 10 completed games on file
Boston Red Sox
87-75 matchup record · 7-3-0 ATS · 3-6-1 O/U
Last 10 completed games on file

Injuries and availability

From the published research (2025-04-06T10:17:25.240Z). Availability may have changed; review the cited sources.

Due to injuries to Brayan Bello and Lucas Giolito, the Red Sox are utilizing Sean Newcomb in their starting rotation. However, Newcomb may face challenges in the upcoming matchup, as the Cardinals have displayed impressive offensive statistics against left-handed pitchers this season, boasting a .910 OPS and 157 wRC+. Nolan Arenado, in particular, has had success against Newcomb, going 7-for-15 with two home runs. Additionally, the current Red Sox lineup has struggled against Miles Mikolas, with only a 6-for-31 record and minimal extra-base hits. Considering these factors, it appears favorable to favor the Cardinals in this game.

Recent head-to-head

  • 2025-04-06St. Louis Cardinals 4 · Boston Red Sox 5
  • 2025-04-04St. Louis Cardinals 9 · Boston Red Sox 13
Final result

Matchup pick recap

Boston Red Sox defeated St. Louis Cardinals 18-7

Boston Red Sox defeated St. Louis Cardinals 18-7 on April 6, 2025, a 11-run decision in the series. Boston Red Sox's strongest period was the 2nd inning, when it outscored its opponent 5-0. Against SportsJaw's recorded St. Louis Cardinals +1.5 (-175) spread, Boston Red Sox covered, while the 25 combined runs finished over the recorded total of 9.5.

SportsJaw editorial picks

  • Projected winnerNo published selectionUnavailable

Tipster picks

  • CovergirlMoneyline · St. Louis Cardinals +105Loss
  • BrycetTotal · Under 9.5 (-110)Loss
  • Steve512Total · Over 9.5 (-110)Win
  • TgodfreyMoneyline · Boston Red Sox -117Win
  • TgodfreyTotal · Over 9.5 (-110)Win
  • MtgoldsteinMoneyline · Boston Red Sox -117Win
  • BluedevilTotal · Over 9.5 (-110)Win
  • PeytoncTotal · Over 9 (-110)Win
  • HopkinspicksMoneyline · Boston Red Sox -122Win
  • JtphamMoneyline · Boston Red Sox +107Win
  • DrpaulMoneyline · Boston Red Sox -122Win
  • RainmanMoneyline · St. Louis Cardinals +107Loss
  • RainmanTotal · Over 9 (-110)Win