Seattle Mariners vs
San Francisco GiantsPredictions & Preview

MLB Betting Action: Giants Favored in Interleague Showdown Against Mariners

On Saturday, April 5, the 2025 MLB betting action includes a full 15-game card, with a highlight being the interleague showdown between the Seattle Mariners and the San Francisco Giants at Oracle Park in San Francisco, CA. The first pitch is set for 9:05 PM ET. The Giants are favored to win with a moneyline of -120, and the total runs are set at 7.5. Starting pitchers will be Bryce Miller for the Mariners and Robbie Ray for the Giants. For more information on this Seattle vs. San Francisco prediction and other MLB picks for Saturday, continue reading.

Betting Odds

• Moneyline: Mariners +110 | Giants -121
• Spread: Mariners +1.5 (-205) | Giants -1.5 (+175)
• Total: Over/Under 7 (-110)
• Based on the moneyline, the implied probability that San Francisco will win straight-up is 55%.

Seattle vs San Francisco Stats

Seattle Mariners

The Seattle Mariners have struggled at the plate in the early stages of the 2025 season, scoring just 18 runs in their first seven games with a .172/.285/.309 slash line. Despite splitting a series with the Athletics and taking one game against the Tigers, they will need to improve offensively to contend for the playoffs. Starting pitcher Bryce Miller, who delayed his second start, will be crucial to the team's success after a solid performance in the previous season. Currently, Seattle is ranked 27th in offense, 18th in defense, and holds a 3-4 record.

San Francisco Giants Analysis

The San Francisco Giants have started the season strong, winning their first two series against the Reds and Astros. They have scored 30 runs while allowing 16 runs in return, with a .202/.273/.399 triple-slash and hitting 10 home runs in 198 at-bats. The bullpen has been exceptional with a 1.74 ERA and 0.82 WHIP in 20.2 innings. Veteran pitcher Robbie Ray is set to start on Saturday after a successful season debut and impressive spring training performance. The Giants currently have a power ranking of 18 and rank #11 for offense, #5 for defense, and hold a 5-1 overall record. Seattle recently went 1-2 in their last three matchups against San Francisco.

Robbie Ray to Face Mariners in Debut Start Against Giants

Bryce Miller is set to make his debut start against the San Francisco Giants, while Robbie Ray will be on the mound for Seattle. Ray, who boasts a 1-1 record, 3.55 ERA, and 1.30 WHIP in six career starts against the Mariners, performed well in his lone meeting with them last season. Ray’s strong pitching performance in spring training indicates he could potentially dominate the Mariners lineup. With Seattle's current struggles against left-handed pitchers, evidenced by their high strikeout rate and below-average offensive production, the odds point to a successful outing for Ray and a favorable outcome for the Giants.

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