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  1. Home
  2. MLB Picks
  3. Houston Astros vs Minnesota Twins
Sat 2:10 PM ET
Houston Astros logo
Houston
Astros1
S. Arrighetti RHP
versus
Minnesota Twins logo
Minnesota
Twins6
B. Ober RHP
Final
Team123456789T
Houston Astros1000000001
Minnesota Twins00060000—

Houston Astros vs Minnesota Twins Betting Picks & Predictions

Game time: April 5, 2025 at 2:10 PM ET

Venue: Target Field — Minneapolis, Minnesota

Article updated Apr 5, 12:45 AM EDT

Published by SportsJaw Editorial Team

The Astros and Twins are set to face off in game two of their series in Minnesota, with the Astros looking to extend their playoff streak in 2025 and the Twins aiming to

Game outlook

The Astros and Twins are set to face off in game two of their series in Minnesota, with the Astros looking to extend their playoff streak in 2025 and the Twins aiming to return to the playoffs after a slow start to the season. The pitching matchup features Spencer Arrighetti for the Astros and Bailey Ober for the Twins. The first pitch is scheduled for 2:10 PM EST, with Minnesota currently holding the betting favorite status. For more details on this Astros/Twins prediction and how it may impact your bankroll, continue reading.

Betting Odds

Moneyline: Astros +105 | Twins -123

Spread: Astros +1.5 (-205) | Twins -1.5 (+175)

Total: Over/Under 7.5 (-110)

Based on the moneyline, the implied probability that Minnesota will win straight-up is 55%.

Houston Astros

The Houston Astros are off to a strong start in the 2025 season, continuing their dominance in the AL West. With two World Series titles in the last eight years, the Astros have established themselves as a top team in the division. They are currently 3-4 on the season, coming off a 5-2 victory over the Twins, with standout performances from Christian Walker and Jeremy Pena. Starter Hunter Brown contributed to the win with a solid performance, allowing two runs in six innings while striking out eight. Looking ahead, the Astros will rely on righty Spencer Arrighetti in game two of the series. Arrighetti has shown promise with a recent win over the Mets, and a strong track record from last season. Despite some key injuries, the Astros are ranked 30th in offense, 10th in defense, and hold a power ranking of 12 in the league.

6
MLB · Houston Astros at Minnesota Twins

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Minnesota Twins Analysis

The Minnesota Twins are currently struggling in the 2025 season, with a current record of 77-85. They recently dropped their home opener to the Astros, scoring only two runs in the first inning before being held in check and ultimately losing 5-2. Key players such as Byron Buxton and pitcher Joe Ryan are trying to lead the team to success, with Bailey Ober set to pitch in the upcoming game in hopes of securing the team's first home win. The Twins are also facing challenges with key injuries to players like Brock Stewart and Royce Lewis. Despite their struggles, the Twins will continue to work towards returning to playoff contention after missing out in 2024.

Twins' Ober Looks to Bounce Back Against Astros, Arrighetti's Performance Uncertain

Although Ober struggled in his first outing, it was an anomaly compared to his exceptional performance last season. Despite allowing two home runs, this was consistent with his performance in the prior season when he gave up 27. In 2024, he significantly improved in keeping runners off base with a WHIP of 1.00. It is anticipated that he will return to form on Saturday against the Astros at home. On the other hand, Arrighetti showed promise in his first outing, however, his inconsistency last season makes it uncertain whether he will have another strong performance on Saturday. With a road record of 4-8 and an ERA close to 5.00 in the previous season, there are doubts about his reliability. The Twins are predicted to secure a victory on Saturday, so consider betting on them with the money line.

SportsJawGame Predictions
Predicted score

Unavailable for this preview

Projected winnerUnavailableConfidencelow
Pick on the Spread

Published pick: Unavailable

Pick on the Total

Published pick: Unavailable

#HoustonAstros#MinnesotaTwins

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Written by

SportsJaw Editorial Team

SportsJaw published this archived preview from its original game-day article. Its prediction and quoted lines are preserved as written.

About our editorial process

SportsJaw Astros vs Twins archived game preview contains historical odds and availability that may no longer be current. View history of past Astros vs Twins matchups or learn how our predictions work.

Current matchup data

Lines, trends and availability

Line movement since open

  • Moneyline · Houston Astros+104 → +110Moved
  • Moneyline · Minnesota Twins-115 → -125Moved
  • Spread · Houston Astros+1.5 (-210) → +1.5 (-196)Moved
  • Spread · Minnesota Twins-1.5 (+180) → -1.5 (+170)Moved
  • Total · Over7.5 (-110) → 7.5 (-110)Unchanged
  • Total · Under7.5 (-110) → 7.5 (-110)Unchanged

ATS and O/U trends

Houston Astros
81-81 matchup record · 3-7-0 ATS · 2-7-1 O/U
Last 10 completed games on file
Minnesota Twins
77-85 matchup record · 2-8-0 ATS · 6-2-2 O/U
Last 10 completed games on file

Injuries and availability

From the published research (2025-04-05T04:45:16.679Z). Availability may have changed; review the cited sources.

The Houston Astros are off to a strong start in the 2025 season, continuing their dominance in the AL West. With two World Series titles in the last eight years, the Astros have established themselves as a top team in the division. They are currently 3-4 on the season, coming off a 5-2 victory over the Twins, with standout performances from Christian Walker and Jeremy Pena. Starter Hunter Brown contributed to the win with a solid performance, allowing two runs in six innings while striking out eight. Looking ahead, the Astros will rely on righty Spencer Arrighetti in game two of the series. Arrighetti has shown promise with a recent win over the Mets, and a strong track record from last season. Despite some key injuries, the Astros are ranked 30th in offense, 10th in defense, and hold a power ranking of 12 in the league.

The Minnesota Twins are currently struggling in the 2025 season, with a current record of 77-85. They recently dropped their home opener to the Astros, scoring only two runs in the first inning before being held in check and ultimately losing 5-2. Key players such as Byron Buxton and pitcher Joe Ryan are trying to lead the team to success, with Bailey Ober set to pitch in the upcoming game in hopes of securing the team's first home win. The Twins are also facing challenges with key injuries to players like Brock Stewart and Royce Lewis. Despite their struggles, the Twins will continue to work towards returning to playoff contention after missing out in 2024.

Recent head-to-head

  • 2025-04-03Houston Astros 5 · Minnesota Twins 2
Final result

Matchup pick recap

Minnesota Twins defeated Houston Astros 6-1

Minnesota Twins defeated Houston Astros 6-1 on April 5, 2025, a 5-run decision in the series. Minnesota Twins' strongest period was the 4th inning, when it outscored its opponent 6-0. Against SportsJaw's recorded Houston Astros +1.5 (-196) spread, Minnesota Twins covered, while the 7 combined runs finished under the recorded total of 7.5.

SportsJaw editorial picks

  • Projected winnerNo published selectionUnavailable

Tipster picks

  • JackCohenMoneyline · Minnesota Twins -123Win