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  1. Home
  2. MLB Picks
  3. St. Louis Cardinals vs Boston Red Sox
Fri 2:10 PM ET
St. Louis Cardinals logo
St. Louis
Cardinals9
E. FEDDE RHP
versus
Boston Red Sox logo
Boston
Red Sox13
W. Buehler RHP
Final
Team123456789T
St. Louis Cardinals0013101039
Boston Red Sox50102032

St. Louis Cardinals vs Boston Red Sox Betting Picks & Predictions

Game time: April 4, 2025 at 2:10 PM ET

Venue: Fenway Park — Boston, Massachusetts

Article updated Apr 3, 10:00 PM EDT

Published by SportsJaw Editorial Team

The St. Louis Cardinals (4-2) will face the Boston Red Sox (2-4) in the first game of their three-game interleague series at Fenway Park on Friday night. Erick Fedde (1-0,

Game outlook

The St. Louis Cardinals (4-2) will face the Boston Red Sox (2-4) in the first game of their three-game interleague series at Fenway Park on Friday night. Erick Fedde (1-0, 1.50 ERA) will start for the Cardinals, while Walker Buehler (0-1, 8.31 ERA) will be on the mound for the Red Sox. Boston is favored to win, opening at -144. Stay tuned to see which team comes out on top in this Cardinals vs. Red Sox matchup.

Betting Odds

Moneyline: Cardinals +128 | Red Sox -144

Spread: Cardinals +1.5 (-161) | Red Sox -1.5 (+134)

Total: Over/Under 9 (-110)

Based on the moneyline, the implied probability that Boston will win straight-up is 59%.

St. Louis Cardinals

The St. Louis Cardinals started their season with a successful six-game home stand, going 4-2. They are now heading on the road for the first time this season in search of their first road win and the series lead. The Cardinals have been performing well offensively, averaging seven runs per game with a .298 batting average, .381 on base percentage, and .498 slugging percentage, ranking them high in the league. Lars Nootbaar leads the team with a .417 batting average, while Ivan Herrera leads in home runs and RBI. Defensively, the Cardinals are giving up an average of 4.16 runs per game, with opponents hitting .181 against them. In their last game, Fedde had a strong outing, allowing only one run in six innings. Currently ranked 6th in offense, 11th in defense, and with a 4-2 record, the Cardinals are looking to continue their success on the road.

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13
MLB · St. Louis Cardinals at Boston Red Sox

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Boston Red Sox Analysis

The Boston Red Sox have started the season with seven consecutive road games and are still seeking their first series win. They will be playing their home opener against the Cardinals on Friday and will aim to secure a victory. Currently, Boston averages 3.16 runs per game with a .217 batting average, ranking 17th in the league. Wilyer Abreu has been a standout performer with a .500 batting average, two home runs, and six RBI. On the defensive side, the Red Sox are giving up 3.50 runs per game with opponents boasting a .259 batting average against them. Despite their performance, Boston has a power ranking of 14 and is ranked 23rd for offense and 13th for defense in the league. Their overall record is 2-4, and they will need a better performance from pitcher Buehler in their upcoming game against the Cardinals. St. Louis previously went 1-2 in their last three matchups against Boston.

St. Louis Cardinals Favored to Win Against Boston Red Sox Due to Recent Form and Matchup Advantages

The St. Louis Cardinals have recently won four out of their last six games, in contrast to the Boston Red Sox who have lost four of their last six games. St. Louis has an advantage in the upcoming game due to their strong performance at the plate against right-handed pitchers, boasting a .309 batting average. Additionally, their opponent, Beuhler, has shown struggles on the mound in his previous start, giving up four runs. With Boston's bullpen also facing challenges, they may find it difficult to contain the Cardinals' offense. On the other hand, Boston's offensive capabilities might be limited as they have a batting average of just over .200 against right-handed pitchers. Fedde, who has a history of success against Boston with a 2-1 record and a 2.20 ERA, is expected to keep their offense in check. Considering these factors, it is advisable to bet on St. Louis for this game.

SportsJawGame Predictions
Predicted score

Unavailable for this preview

Projected winnerUnavailableConfidencelow
Pick on the Spread

Published pick: Unavailable

Pick on the Total

Published pick: Unavailable

#StLouisCardinals#BostonRedSox

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Written by

SportsJaw Editorial Team

SportsJaw published this archived preview from its original game-day article. Its prediction and quoted lines are preserved as written.

About our editorial process

SportsJaw Cardinals vs Red Sox archived game preview contains historical odds and availability that may no longer be current. View history of past Cardinals vs Red Sox matchups or learn how our predictions work.

Current matchup data

Lines, trends and availability

Line movement since open

  • Moneyline · St. Louis Cardinals+128 → +100Moved
  • Moneyline · Boston Red Sox-144 → -112Moved
  • Spread · St. Louis Cardinals+1.5 (-161) → +1.5 (-190)Moved
  • Spread · Boston Red Sox-1.5 (+134) → -1.5 (+165)Moved
  • Total · Over9 (-110) → 9.5 (-110)Moved
  • Total · Under9 (-110) → 9.5 (-110)Moved

ATS and O/U trends

St. Louis Cardinals
77-85 matchup record · 7-3-0 ATS · 8-2-0 O/U
Last 10 completed games on file
Boston Red Sox
87-75 matchup record · 6-4-0 ATS · 3-7-0 O/U
Last 10 completed games on file

Injuries and availability

From the published research (2025-04-04T02:00:21.078Z). Availability may have changed; review the cited sources.

No verified injury or availability note was included in the published matchup research.

Recent head-to-head

No completed head-to-head result is available in the current history window.

Final result

Matchup pick recap

Boston Red Sox defeated St. Louis Cardinals 13-9

Boston Red Sox defeated St. Louis Cardinals 13-9 on April 4, 2025, a 4-run decision in the series. Boston Red Sox's strongest period was the 1st inning, when it outscored its opponent 5-0. Against SportsJaw's recorded St. Louis Cardinals +1.5 (-190) spread, Boston Red Sox covered, while the 22 combined runs finished over the recorded total of 9.5.

SportsJaw editorial picks

  • Projected winnerNo published selectionUnavailable

Tipster picks

  • Novacek84Total · Over 9 (-110)Win
  • HitmanhartMoneyline · St. Louis Cardinals +128Loss
  • MikeVargasMoneyline · Boston Red Sox +128Win
  • 1118240754Moneyline · St. Louis Cardinals +128Loss
  • Altuve27Moneyline · St. Louis Cardinals +128Loss
  • JeffjacksonMoneyline · Boston Red Sox -135Win
  • RainmanTotal · Over 9 (-110)Win
  • KrockpicksMoneyline · St. Louis Cardinals +125Loss
  • EXCELent Sports PicksTotal · Under 9 (-110)Loss