Tampa Bay Rays vs
San Diego PadresPredictions & Preview

Padres Favored in Sunday Showdown Against Rays, San Diego Looking to Even Series

The MLB betting action for Sunday, April 27, 2025, includes a 16-game card with an interleague showdown at Petco Park in San Diego, California between the Rays and Padres. The Rays narrowly defeated the Padres 1-0 in the series opener, with the Padres now favored at -115 for the closer. The starting pitchers will be Zack Littell for the Rays and Randy Vasquez for the Padres. San Diego opened as the slight favorite at -118, with the betting line remaining steady. The total runs for the game is set at 8.0. Stay updated with this Tampa Bay vs. San Diego prediction and other MLB picks for Sunday's games.

Betting Odds

• Moneyline: Rays +107 | Padres -118
• Spread: Rays -1.5 (+164) | Padres +1.5 (-200)
• Total: Over/Under 8 (-110)
• Based on the moneyline, the implied probability that San Diego will win straight-up is 54%.

Tampa Bay vs San Diego Stats

Tampa Bay Rays

The Tampa Bay Rays extended their winning streak to three games with a 1-0 victory over the Padres on Friday night. Shane Baz pitched seven strong innings, while Yandy Diaz's sacrifice fly in the third inning lifted the Rays to victory. Tampa Bay ranks 16th in offense, scoring an average of 4.23 runs per game, and 8th in defense, allowing an average of 3.88 runs per game. The team has a record of 12-14 this season. Zack Littell, with a 0-5 record and a 5.28 ERA, will take the mound on Sunday.

San Diego Padres Analysis

In the opening game of the series, the San Diego Padres struggled offensively, mustering just five hits and failing to score for the second straight outing. This loss marked their fifth defeat in seven games, during which they have only scored 15 runs. The Padres typically average 3.96 runs per game, ranking 22nd in the majors, with a .260/.329/.394 slash line and slugging 40 doubles, a triple, and 24 homers through 26 games and 850 at-bats in the 2025 season. However, the Padres are facing injury concerns with CF Jackson Merrill, 1B Luis Arraez, and 2B Jake Cronenworth unavailable. On the defensive side, the Padres allow just 2.88 runs per game, ranking 2nd in the league. Randy Vasquez will be starting Sunday's game with a 1-2 record, a 3.97 ERA, and a 1.59 WHIP in five starts this season. In his last outing, Vasquez struggled, giving up six earned runs in a 6-4 defeat to the Detroit Tigers. Despite their recent struggles, the Padres hold a power ranking of 3 and are currently 17-9 overall. In their last three matchups, the Tampa Bay Rays went 1-2 against the San Diego Padres.

San Diego Padres Struggling at Plate, Predicted to Fall to Tampa Bay Rays in Sunday Showdown

The San Diego Padres have faced recent challenges at the plate, particularly missing key players such as Jackson Merrill, Luis Arraez, and Jake Cronenworth. Their performance against right-handed pitchers in the past 10 days has been subpar with a .565 OPS and 66 wRC+. As a result, I am predicting a victory for Tampa Bay in the upcoming Sunday afternoon game. While the current Padres have had some success against Zack Littell, he has shown improvement in his recent starts and is likely to break his losing streak soon. On the other hand, Randy Vasquez has struggled against the Rays, who have had success against him. Despite both teams' lackluster performance against right-handed pitchers, both bullpens have been reliable throughout the season. This sets the stage for a competitive and closely-contested game.

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