Tampa Bay Rays vs
Arizona DiamondbacksPredictions & Preview

Arizona Diamondbacks Favored Over Tampa Bay Rays in Wednesday's Interleague Matchup at Chase Field

The 2025 Major League Baseball season continues on Wednesday, April 23, with the Tampa Bay Rays facing off against the Arizona Diamondbacks in the second game of their three-game interleague series at Chase Field in Phoenix, AZ. This prediction article was written prior to Tuesday's game, with the analysis focusing solely on Wednesday's matchup. The Diamondbacks are currently listed as -135 moneyline favorites, with the total set at 9.0 runs. Taj Bradley (ERA: 5.24) is set to pitch for the Rays, while Eduardo Rodriguez (ERA: 4.09) will take the mound for the Diamondbacks. Arizona opened as -140 favorites and the line has remained steady. Be sure to read on for more insight into this Tampa Bay vs. Arizona prediction, as well as other MLB picks for Wednesday's slate of games.

Betting Odds

• Moneyline: Rays +127 | Diamondbacks -140
• Spread: Rays +1.5 (-182) | Diamondbacks -1.5 (+150)
• Total: Over/Under 9 (-110)
• Based on the moneyline, the implied probability that Arizona will win straight-up is 58%.

Tampa Bay vs Arizona Stats

Tampa Bay Rays

The Tampa Bay Rays recently completed a 13-game homestand with a 4-0 loss to the New York Yankees, marking their fifth loss in six games. Despite being last in the AL East as of Tuesday morning, they rank 12th in the majors in slugging percentage and ninth in OPS. However, their recent offensive performance has been lacking, with a slash line of .209/.292/.298 over the past six games. On the positive side, their bullpen has been strong with a 1.99 ERA and 0.93 WHIP. Taj Bradley is set to pitch at Chase Field on Wednesday night, with a record of 2-1 this season. In his last outing against the Yankees, he struggled, allowing six earned runs in 5.1 innings. The team currently has a power ranking of 13 and is ranked 14th in offense and 8th in defense, with a record of 9-13 for the season.

Arizona Diamondbacks Analysis

The Arizona Diamondbacks concluded a successful six-game road trip with an extra-inning victory over the Chicago Cubs, avoiding a sweep and securing their eighth win in 11 games. Currently ranked fourth in the NL West, the Diamondbacks boast impressive offensive statistics, ranking third in slugging percentage and OPS in the majors. However, their bullpen has struggled with a high ERA, WHIP, and batting average against. Eduardo Rodriguez is set to pitch in the upcoming game, with a mixed record this season and previous struggles against the Tampa Bay Rays. The Diamondbacks have a strong offense but a weaker defense, with a power ranking of 6 and a 13-9 overall record. They have historically performed well against Tampa Bay, winning their last three matchups.

Tampa Bay Rays Struggle against Lefties, Arizona Diamondbacks Favorable Matchup Ahead

Only a handful of players on the Tampa Bay team have faced Eduardo Rodriguez in the past, resulting in a batting average of .278 with a double and three home runs. Yandy Diaz and Brandon Lowe account for the majority of these hits, with 13 out of 15 hits coming from them. Recently, the Rays have struggled against left-handed pitchers, with a .644 OPS and 99 wRC+ over the last 10 days, making the Arizona Diamondbacks appear to be the stronger offensive team. The current Diamondbacks have a .280 batting average with a double and three home runs against Taj Bradley. Against right-handed pitchers in the past 10 days, Arizona has recorded a .792 OPS and 118 wRC+. Despite a weaker bullpen, I am inclined to favor the Diamondbacks in this matchup.

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