Tampa Bay Rays vs
Arizona DiamondbacksPredictions & Preview

Tampa Bay Rays Look to Extend Winning Streak Against Arizona Diamondbacks in MLB Showdown

The 2025 MLB betting action continues on Tuesday, April 22, with a highlighted matchup between the Tampa Bay Rays and the Arizona Diamondbacks. The Rays, with a record of 9-13, will face the 13-9 Diamondbacks in a three-game series at Chase Field in Phoenix, AZ. The Rays are looking for their sixth consecutive victory over the Diamondbacks. In Tuesday's opener, the Rays are listed as +135 road underdogs, while the Diamondbacks are favored at -155 on the moneyline with a total of 9.0 runs. Zack Littell (ERA: 5.48) will start for the Rays, and Brandon Pfaadt (ERA: 3.04) will start for the Diamondbacks. Arizona opened as -147 favorites, and the line has remained steady. Stay informed with our Tampa Bay vs. Arizona prediction and explore all of our MLB picks for Tuesday's slate. The first pitch is scheduled for 9:40 PM ET.

Betting Odds

• Moneyline: Rays +133 | Diamondbacks -147
• Spread: Rays +1.5 (-152) | Diamondbacks -1.5 (+126)
• Total: Over/Under 9 (-110)
• Based on the moneyline, the implied probability that Arizona will win straight-up is 60%.

Tampa Bay vs Arizona Stats

Tampa Bay Rays

The Tampa Bay Rays have had a mix of success and struggles in the early part of the 2025 season. After starting strong with series victories against the Colorado Rockies and Pittsburgh Pirates, the team has only won one of their last six games. They have faced tough competition from the Boston Red Sox and New York Yankees, resulting in losses. Despite scoring 33 runs in their last few games, nearly half of those came in one dominant victory. Zack Littell will be the starting pitcher for the Rays in their upcoming game, with a record of 0-4 and a 5.48 ERA this season. The team is currently ranked 14th in offense, 8th in defense, and have a 9-13 record.

Arizona Diamondbacks Analysis

Despite missing one of their best players, second baseman Ketel Marte, the Arizona Diamondbacks have won three of their last four series, going 8-4 in the process. Marte has been performing exceptionally well in his first eight games of the season. The Diamondbacks recently completed a six-game road trip, sweeping the Miami Marlins but losing two out of three games against the Chicago Cubs. Brandon Pfaadt is set to pitch on Tuesday with a strong record so far this season. The Diamondbacks have a power ranking of 2 and are ranked #3 for offense, scoring an average of 5.57 runs per game. Their defense is ranked #27, giving up an average of 4.81 runs per game. They currently have a 13-9 overall record and Tampa Bay lost their last three matchups against Arizona.

Rookie Brandon Pfaadt Shines While Zack Littell Faces Uncertainty in Upcoming Matchup

In 2023, Brandon Pfaadt, a rookie, showcased his skills in the Rays' lineup, which was notably more potent than it is currently. Pfaadt's performance this season has been commendable, and his upcoming matchup against the Rays is anticipated to be strong, particularly as only two players from Tampa Bay have faced him previously. On a contrasting note, Zack Littell's recent starts have presented a mixed bag of outcomes, making his performance at Chase Field uncertain. Littell's inconsistency is reflected in his barrel percentage in the 11th percentile and hard-hit percentage in the 23rd percentile. Although the Diamondbacks have a limited 3-for-23 record against Littell, their consistent slugging percentage and wRC+ against right-handed pitchers in the last five games indicate a potential advantage over the Rays, who have struggled in this aspect. Littell's transition from the bullpen to the starting role raises concerns about his reliability in this new position.

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