San Diego Padres vs
Detroit TigersPredictions & Preview

Tigers Favored Over Padres in Interleague Matchup at Comerica Park

On Monday, April 21, the 2025 Major League Baseball season will feature eight games, including an interleague matchup at Comerica Park in Detroit between the Padres and Tigers. The Padres have had success against the Tigers in recent meetings, winning four out of their last six contests. The starting pitchers for this game will be Randy Vasquez for the Padres and Keider Montero for the Tigers. Detroit is the betting favorite for this matchup, opening at -129. The game is scheduled to begin at 6:40 PM ET. For more information on this Padres vs. Tigers prediction and other MLB picks for Monday, continue reading.

Betting Odds

• Moneyline: Padres +113 | Tigers -128
• Spread: Padres +1.5 (-182) | Tigers -1.5 (+160)
• Total: Over/Under 8.25 (-110)
• Based on the moneyline, the implied probability that Detroit will win straight-up is 56%.

San Diego vs Detroit Stats

San Diego Padres

Prior to Sunday's results, the San Diego Padres, with a record of 15-6, faced the Houston Astros in hopes of avoiding a sweep in their three-game series. Despite losing the first two games, including blowing a two-run lead in the middle game, the Padres' lineup has been impacted by injuries to key players. Over their last five games, they have recorded a .251/.333/.404 triple-slash with eight doubles and six home runs. For the season, the Padres are slashing .275/.344/.419 with 37 doubles and 21 home runs. Randy Vasquez is set to pitch against the Tigers, boasting a 1-1 record with a 1.74 ERA in four starts this season. The Padres, ranked 13 in offense and second in defense, have a power ranking of 3 and a record of 16-6.

Detroit Tigers Analysis

The Detroit Tigers hosted the Kansas City Royals in a four-game series, aiming to sweep the divisional rivals after outscoring them 16-5 in the first three games. Detroit has been successful at home in 2025, with a .245/.323/.394 hitting line and strong pitching performances. Third baseman Matt Vierling, catcher Jake Rogers, and outfielders Wenceel Perez and Manuel Margot are unavailable for the Tigers. Pitcher Jack Flaherty, with a 2.53 ERA, will start for Detroit. The Tigers are ranked 4th with a strong offense and defense, scoring an average of 4.62 runs per game and allowing 3.43 runs per game. In their last three matchups, San Diego went 1-2 against Detroit.

San Diego Padres Face Tough Matchup Against Jack Flaherty and Detroit Tigers

The San Diego lineup has had success against Jack Flaherty, boasting a 17-for-57 record with six doubles and two home runs. Of particular note is Fernando Tatis, who has an impressive 7-for-10 record with four doubles and two home runs against Flaherty. However, Flaherty has shown strong performances in his two home starts this season, allowing just one run. His recent 5.1 scoreless innings against the Yankees demonstrated his pitching prowess, with only three hits allowed and nine strikeouts. This matchup presents a challenge for the Padres, who are coming off a tiring night game in Houston. Despite limited experience against Randy Vasquez, the Tigers have shown some success at the plate. Both bullpens have been solid in April, with the Padres boasting a 2.00 ERA and 3.37 FIP, and the Tigers holding a 2.25 ERA and 3.64 FIP.

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