San Diego Padres vs Detroit Tigers Betting Picks & Predictions
On Monday, April 21, the 2025 Major League Baseball season will feature eight games, including an interleague matchup at Comerica Park in Detroit between the Padres and
Game outlook
On Monday, April 21, the 2025 Major League Baseball season will feature eight games, including an interleague matchup at Comerica Park in Detroit between the Padres and Tigers. The Padres have had success against the Tigers in recent meetings, winning four out of their last six contests. The starting pitchers for this game will be Randy Vasquez for the Padres and Keider Montero for the Tigers. Detroit is the betting favorite for this matchup, opening at -129. The game is scheduled to begin at 6:40 PM ET. For more information on this Padres vs. Tigers prediction and other MLB picks for Monday, continue reading.
Betting Odds
Moneyline: Padres +113 | Tigers -128
Spread: Padres +1.5 (-182) | Tigers -1.5 (+160)
Total: Over/Under 8.25 (-110)
Based on the moneyline, the implied probability that Detroit will win straight-up is 56%.
San Diego Padres
Prior to Sunday's results, the San Diego Padres, with a record of 91-71, faced the Houston Astros in hopes of avoiding a sweep in their three-game series. Despite losing the first two games, including blowing a two-run lead in the middle game, the Padres' lineup has been impacted by injuries to key players. Over their last five games, they have recorded a .251/.333/.404 triple-slash with eight doubles and six home runs. For the season, the Padres are slashing .275/.344/.419 with 37 doubles and 21 home runs. Randy Vasquez is set to pitch against the Tigers, boasting a 76-86 record with a 1.74 ERA in four starts this season. The Padres, ranked 13 in offense and second in defense, have a power ranking of 3 and a record of 91-71.