San Diego Padres vs
Houston AstrosPredictions & Preview

Astros Favored in Interleague Showdown Against Padres on Sunday Night Baseball at Daikin Park

Sunday Night Baseball will feature an interleague showdown between the San Diego Padres and Houston Astros at Daikin Park in Houston, Texas, with the first pitch at 7:00 PM ET. The Astros currently lead the regular-season series after winning the opener 6-4 last Friday. In this Padres vs. Astros prediction, the Astros are favored with a moneyline of -120 and a total of 7.5 runs. Dylan Cease will be starting for the Padres, while Framber Valdez will take the mound for the Astros. The current line favors Houston at -120.

Betting Odds

• Moneyline: Padres +106 | Astros -120
• Spread: Padres +1.5 (-200) | Astros -1.5 (+170)
• Total: Over/Under 7.5 (-110)
• Based on the moneyline, the implied probability that Houston will win straight-up is 55%.

San Diego vs Houston Stats

San Diego Padres

The San Diego Padres have been performing well on both offense and defense this season, boasting a .279/.349/.421 slash line with 34 doubles and 20 home runs at the plate, and a strong 2.75 ERA, 1.10 WHIP, and .202 batting average against from their pitching staff. RF Fernando Tatis and CF Jackson Merrill have been standouts, but Merrill is currently on the IL with a hamstring injury along with 2B Jake Cronenworth. Dylan Cease is set to pitch next, despite struggling with a 6.64 ERA this season. Despite this, the Padres have a power ranking of 3 and are ranked 10 in offense, #1 in defense, and have a record of 15-6 so far this season.

Houston Astros Analysis

The Houston Astros have struggled with inconsistency in the 2025 season so far. Their offense has not been performing well, hitting just .223/.304/.332 with minimal extra-base hits. However, their pitching has been solid, boasting a 3.4 ERA, 1.14 WHIP, and .214 opposing batting average. Jose Altuve leads the team with a .798 OPS and Yordan Alvarez has driven in 10 runs despite a subpar batting average. Framber Valdez is set to pitch next, with a mixed track record of strong outings and poor performances. The Astros are ranked 13th in power rankings and have a 10-10 overall record. In their last three matchups, the San Diego Padres have won two out of three games against the Astros.

Padres and Astros Brace for Matchup: Offensive Performance and Pitching Matchups Analyzed

The San Diego Padres have a current batting average of .241 against Framber Valdez, with 14 hits in 58 at-bats, including four doubles and two home runs. Key players such as Fernando Tatis Jr. and Luis Arraez have struggled at 1-for-7 each, while Manny Machado is 1-for-6 against Valdez. On the other hand, the Houston Astros have a .146 batting average against Dylan Cease, with just 14 hits in 96 at-bats. Jose Altuve has been a standout performer with a 5-for-15 record and two home runs against Cease. Both teams have shown solid offensive performances lately, with the Padres boasting a 110 wRC+ against southpaw pitchers and the Astros holding a 108 wRC+ against right-handed pitchers in the last 10 days. While both teams have strong bullpens, the Astros have a slight edge due to the absence of key players in the Padres lineup such as Jackson Merrill and Jake Cronenworth.

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