San Francisco Giants vs
Los Angeles AngelsPredictions & Preview

Giants Favored in Interleague Showdown Against Angels - Betting Line Set at -140 for San Francisco

The 2025 MLB betting action continues on Saturday, April 19, with an interleague showdown between the San Francisco Giants and Los Angeles Angels at Angel Stadium in Anaheim, California. The Giants are favored in this matchup, with Landen Roupp taking the mound for San Francisco against Kyle Hendricks for the Angels. The current betting line has San Francisco at -140. Stay informed with our Giants vs. Angels prediction and analysis for Saturday's game.

Betting Odds

• Moneyline: Giants -140 | Angels +124
• Spread: Giants -1.5 (+116) | Angels +1.5 (-135)
• Total: Over/Under 8.5 (-110)
• Based on the moneyline, the implied probability that San Francisco will win straight-up is 58%.

San Francisco vs Los Angeles Stats

San Francisco Giants

The San Francisco Giants recently split a four-game road series against the Philadelphia Phillies, following their successful series against the Yankees in New York. Despite outscoring the Phillies 29-20, the Giants were only able to secure two wins at Citizens Bank Park in Philadelphia. The team is currently hitting .231/.308/.415 with 23 home runs in 646 at-bats, leading the majors in doubles and ranking 14th in stolen bases. The Giants bullpen has been performing well with a 1.89 ERA, 1.01 WHIP, and .181 batting average against in 66.2 innings of work. Landen Roupp is set to pitch at Angel Stadium on Saturday with a 1-1 record, 4.80 ERA, and 1.60 WHIP in three starts this season. Despite a shaky recent performance, the 26-year-old right-hander earned his first win of the season against the Phillies. Last season, Roupp posted a 3.58 ERA and 1.37 WHIP in 50.1 innings. The Giants currently have a power ranking of 10, ranking 4th in offense, 6th in defense, and are currently 13-7 this season.

Los Angeles Angels Analysis

The Los Angeles Angels recently completed a challenging nine-game road trip with a 3-6 record, facing losses against the Texas Rangers, Houston Astros, and Tampa Bay Rays. The team is currently struggling with a .230/.292/.419 slash line and their bullpen has a high ERA of 5.91. Kyle Hendricks is set to start against the San Francisco Giants with a 0-1 record this season but has a strong history against the Giants in past matchups. The Angels are currently ranked 29th in power rankings, with a solid offense but struggling defense. San Francisco has won 2 out of their last 3 games against the Angels.

San Francisco Giants look to capitalize on success against Kyle Hendricks in matchup against Los Angeles Angels

The current statistics show that the San Francisco Giants have displayed difficulty facing Kyle Hendricks, with a collective 13-for-89 batting average, including three doubles and four home runs. The exception to this is LaMonte Wade Jr., who boasts a 4-for-11 record with two home runs against Hendricks. Hendricks, on the other hand, has no previous pitching experience at Angel Stadium. Recent performance indicators suggest that both teams have been successful against right-handed pitchers, with the Los Angeles Angels recording a 108 wRC+ and the Giants a 138 wRC+ over the past 10 days. Anticipating a closely contested match, my preference is for the Giants due to their strong bullpen. Additionally, only three players from the Angels team have faced Landen Roupp, with a combined 0-for-3 record, while the Angels' bullpen has struggled thus far in the season.

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