Chicago White Sox vs
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Red Sox Favored to Win Against White Sox in Fenway Park Rematch: Latest Prediction Shows Boston as Betting Favorite

The fifth White Sox vs. Red Sox prediction indicates that the upcoming Saturday matchup at 4:10 p.m. EST will take place at Fenway Park. The Chicago White Sox (4-14; 0-6 away) previously won two out of three games against the Boston Red Sox (10-10; 4-3 home) in their last meeting. With Shane Smith and Garrett Crochet as the starting pitchers for their respective teams, Boston is the betting favorite at -300. Stay informed about this weekend's games and the entire 2025 season by reading the full White Sox vs. Red Sox prediction.

Betting Odds

• Moneyline: White Sox +265 | Red Sox -300
• Spread: White Sox +1.5 (+120) | Red Sox -1.5 (-144)
• Total: Over/Under 8.5 (-110)
• Based on the moneyline, the implied probability that Boston will win straight-up is 75%.

Chicago vs Boston Stats

Chicago White Sox

The White Sox have struggled on the road this season, being swept in both of their road series. Their offense ranks 28th in scoring and dead last in batting average, OBP, and slugging percentage. Additionally, they are 26th in home runs and 17th in stolen bases. However, pitcher Shane Smith has been performing well, allowing only two runs in each of his starts. The rest of the bullpen is ranked 23rd in ERA, 22nd in FIP, and 21st in WAR. Chicago faces a tough challenge against the Red Sox, who have a power ranking of 20 and are ranked 28th in offense and 11th in defense.

Boston Red Sox Analysis

The Boston Red Sox struggled offensively during their series in Chicago last weekend, scoring only six total runs. However, their offense has been much stronger at Fenway Park, scoring 44 runs in seven home games. Overall, the team ranks 14th in runs per game, 10th in batting average, 12th in OBP, and 15th in slugging. They excel in stolen bases and have a high success rate, but struggle with walk rate, home runs, and strikeout rate. Former White Sox starter Garrett Crochet will face his former team once again, after a successful outing last weekend. The Boston bullpen ranks high in WAR and FIP. The Red Sox have a power ranking of 18 and currently hold a record of 10-10. Chicago has struggled in their last three matchups against Boston, with a 1-2 record. It remains to be seen if the Red Sox will come out on top in their upcoming game against Chicago.

Red Sox Poised for Victory in Fenway Rematch Against Chicago

The recent starting pitcher matchup occurred less than a week ago, resulting in a decisive victory for Boston on the road. As the series moves to Fenway, the Red Sox are poised for another comfortable win. Their offense maintains a strong .755 OPS and averages 6.29 runs per game at home, which should prove challenging for Smith and Chicago's vulnerable bullpen. While Crochet demonstrated his ability to shut down weak offenses in the previous game, Boston's bullpen is also equipped to handle the task. Overall, it is advisable to favor the Red Sox to secure another multiple-run victory in this upcoming matchup.

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