Seattle Mariners vs
Cincinnati RedsPredictions & Preview

Mariners vs. Reds: Bryce Miller Leads Seattle to Victory in Interleague Showdown

The 2025 Major League Baseball season continues with an interleague showdown between the Seattle Mariners and Cincinnati Reds at Great American Ball Park in Cincinnati, Ohio on Wednesday, April 16. Both teams are coming off a day of rest and looking to continue their good form in the middle game of a three-game series. The starting pitchers will be Bryce Miller for the Mariners and Nick Martinez for the Reds. Seattle is the betting favorite with odds opening at -120 and the line has remained steady. For more information on this matchup and other MLB picks for Wednesday's games, be sure to read our in-depth analysis.

Betting Odds

• Moneyline: Mariners -120 | Reds +105
• Spread: Mariners -1.5 (+135) | Reds +1.5 (-156)
• Total: Over/Under 8.5 (-110)
• Based on the moneyline, the implied probability that Seattle will win straight-up is 55%.

Seattle vs Cincinnati Stats

Seattle Mariners

The Seattle Mariners recently swept a three-game series against the Texas Rangers, extending their winning streak to four games. In the last four games, the team has shown improvement in their offensive performance, recording a .242/.331/.452 slash line with six home runs. Their pitching staff ranks eighth in ERA (3.54) and 17th in WHIP (1.28) in the majors. Bryce Miller is set to pitch in the upcoming game, with a slow start to the season but showing improvement in his last outing. Seattle is currently ranked 12th in power rankings, with a ranking of 23 in offense, 11th in defense, and a 8-9 record for the season.

Cincinnati Reds Analysis

The Cincinnati Reds are on a hot streak, looking to secure their third straight series victory after defeating the San Francisco Giants and sweeping the Pittsburgh Pirates. The pitching staff has been exceptional with a 2.87 ERA, 0.92 WHIP, and .184 batting average against. However, the team's offense has struggled, with a .200/.272/.320 triple-slash. Nick Martinez is set to start the next game, with a 0-2 record and 6.06 ERA. The Reds currently have a power ranking of 10 and are ranked #22 for offense, scoring an average of 3.88 runs per game, and #3 for defense, giving up an average of 3.19 runs per game. Overall, the Reds are 9-8 for the season, with a recent 1-2 record against the Seattle Mariners.

Bryce Miller Shines Against Reds as Mariners Secure Victory

Bryce Miller has a strong track record against the Reds, boasting a 1-0 record with a 1.64 ERA in two career starts against them. His performance at Great American Ball Park in 2023 was particularly notable, allowing just one earned run on seven hits across five innings. With the Reds struggling against right-handed pitchers in recent games, Miller is poised to deliver another solid performance. On the other hand, Nick Martinez has struggled in his recent outings, with a 0-3 record and 4.41 ERA in his five career starts against the Mariners. Considering the Mariners' success at the plate against Martinez, it is reasonable to expect them to continue improving and secure a victory in this matchup. With these factors in mind, I predict the Mariners to come out on top in this game.

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