Houston Astros vs
St. Louis CardinalsPredictions & Preview

Astros Favored Over Cardinals in Interleague Clash, According to MLB Picks for Tuesday's Slate

On Tuesday, April 15, 2025, the MLB will feature a full 15-game card, including an interleague clash between the Houston Astros and St. Louis Cardinals at Busch Stadium in St. Louis, Missouri. The Astros are currently favored with a -120 moneyline for the game, with the total set at 7.5 runs. Starting pitchers will be Hunter Brown (ERA: 2) for the Astros and Erick Fedde (ERA: 4.2) for the Cardinals. For a more in-depth analysis of this matchup and other MLB picks for Tuesday's slate, continue reading.

Betting Odds

• Moneyline: Astros -121 | Cardinals +110
• Spread: Astros -1.5 (+150) | Cardinals +1.5 (-168)
• Total: Over/Under 7.5 (-110)
• Based on the moneyline, the implied probability that Houston will win straight-up is 55%.

Houston vs St. Louis Stats

Houston Astros

The Houston Astros recently won a three-game set against the Los Angeles Angels, with comfortable victories of 14-3 and 7-3 sandwiching a 4-1 defeat. Despite their solid 3.69 ERA and 1.06 WHIP, the Astros are looking for more from their offense, as they have scored 60 runs with a .219/.309/.320 slash line in their first 15 games. Hunter Brown, with a 2-0 record, 2.00 ERA, and 0.78 WHIP, will take the mound against the Cardinals on Tuesday. Houston is currently ranked 20th in offense, 10th in defense, and has a record of 7-8 this season.

St. Louis Cardinals Analysis

The St. Louis Cardinals emerged victorious in a recent three-game series against the Philadelphia Phillies, securing wins with scorelines of 2-0 and 7-0, and suffering a 4-1 loss. The Cardinals have shown strong offensive performance this season, scoring 82 runs in their first 15 games with an impressive batting average of .280/.350/.435. Their pitching staff has also performed well, maintaining a 4.48 ERA and a .226 batting average against. Pitcher Erick Fedde will be taking the mound next, with a 1-1 record and 4.20 ERA. The Cardinals currently hold a power ranking of 7 and are ranked 3rd for offense, scoring an average of 5.36 runs per game. In their last three matchups with the Houston Astros, the Cardinals emerged victorious in two out of the three games.

Astros Favored to Dominate in Matchup Against Cardinals and Hunter Brown

The upcoming matchup between the Cardinals and Hunter Brown presents a unique challenge for the team, as Brown has demonstrated exceptional performance in his first three starts this season. Ranking in the 93rd percentile in chase rate and the 88th percentile in hard-hit percentage, Brown is poised to present difficulties for the Cardinals' hitters. In contrast, Erick Fedde's performance has been less consistent, with metrics placing him in the 32nd percentile in expected ERA, 26th percentile in chase rate, and 66th percentile in hard-hit percentage. Fedde's recent struggles against the Red Sox, followed by a notable showing against the Pirates, indicate potential volatility in his performance. Given Houston's promising offensive displays in previous games, and historical success against Fedde, the Astros are favored to perform well in this matchup. It is recommended to consider Houston at the moneyline for this game.

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