San Francisco Giants vs
New York YankeesPredictions & Preview

Yankees Favored to Win Interleague Showdown Against Giants at Yankee Stadium

On Friday, April 11, the 2025 MLB betting action features a full 15-game slate, including an interleague showdown between the San Francisco Giants and the New York Yankees at Yankee Stadium in Bronx, New York. The Yankees have historically had the upper hand against the Giants, sweeping a three-game road series last season. With starting pitchers Robbie Ray for the Giants and Marcus Stroman for the Yankees, New York is favored to win with a -128 opening line that has not moved. The game is set to begin at 7:05 PM ET.

Betting Odds

• Moneyline: Giants +115 | Yankees -128
• Spread: Giants +1.5 (-182) | Yankees -1.5 (+160)
• Total: Over/Under 8 (-110)
• Based on the moneyline, the implied probability that New York will win straight-up is 56%.

San Francisco vs New York Stats

San Francisco Giants

The San Francisco Giants are off to a strong start this season, winning nine of their first 12 games. They recently finished a successful homestand with a 4-2 record, including a dramatic extra-innings victory over the Cincinnati Reds to avoid a sweep. The Giants are averaging 4.75 runs per game, ranking 11th in the majors, and have a .228/.288/.404 triple-slash. They have a strong defense, allowing just 3.25 runs per game, which is 2nd in the league. The bullpen has been solid, with a 1.79 ERA and 1.13 WHIP over 45.1 innings pitched. Pitcher Robbie Ray is set to start against the Yankees with a 2-0 record, 3.18 ERA, and 1.15 WHIP in two starts this season. The Giants are currently ranked 14th in offense, 2nd in defense, and have a record of 9-3.

New York Yankees Analysis

The New York Yankees defeated the Detroit Tigers 4-3 to improve to 7-5 on the season and avoid a sweep in a recent series. Max Fried pitched a strong game with 11 strikeouts in seven scoreless innings, while Devin Williams had a shaky ninth inning. The Yankees lead the league in runs per game and have hit 26 home runs, with Aaron Judge leading the team in offensive stats. The bullpen has a 3.97 ERA and 1.17 WHIP. Marcus Stroman is set to start his third game of the season, with a 7.27 ERA so far. The Yankees have a power ranking of 1, ranking high in offense but lower in defense. San Francisco has won their last three matchups against New York.

Robbie Ray Faces Tough Test Against Yankees' Potent Lineup

Robbie Ray demonstrated an impressive performance against the Mariners in his previous outing, despite issuing five walks. However, the upcoming matchup against the Yankees presents a more challenging task. Although the current Yankees lineup has struggled against Ray with a 7-for-38 record, their success against left-handed pitchers this season should not be overlooked, boasting a .911 OPS and 162 wRC+ over 221 plate appearances. Aaron Judge, in particular, has had success against Ray, hitting three home runs in eight at-bats. While Marcus Stroman's pitching performance raises some concerns, the strength of the Yankees' offense will play a pivotal role in determining the outcome of the game.

Sources: [ 2 ] [ 3 ]