Cleveland Guardians vs
San Diego PadresPredictions & Preview

Padres Favored Over Guardians in Interleague Showdown at Petco Park: Betting Odds and Starting Pitchers Analyzed

In this preview of the upcoming Guardians vs. Padres matchup at Petco Park in San Diego, CA, we analyze the betting odds and starting pitchers for the interleague showdown. The Padres are currently favored at -175 and the total runs are set at 7.5. Logan Allen will start for Cleveland with a perfect ERA, while Michael King takes the mound for San Diego with an ERA of 10.12. Stay tuned for our prediction and be sure to check out all of our MLB picks for Tuesday's games.

Betting Odds

• Moneyline: Guardians +144 | Padres -168
• Spread: Guardians +1.5 (-150) | Padres -1.5 (+130)
• Total: Over/Under 7.5 (-110)
• Based on the moneyline, the implied probability that San Diego will win straight-up is 63%.

Cleveland vs San Diego Stats

Cleveland Guardians

The Cleveland Guardians began their 2025 season with a successful three-game road series against the Kansas City Royals, winning two out of three games. The team displayed an impressive slash line of .263/.336/.485, hitting five doubles, a triple, and five home runs in 99 at-bats. LF Steven Kwan and DH Kyle Manzardo had standout performances at the plate. However, 3B Jose Ramirez missed Sunday's game due to a wrist injury but was expected to return for the next game against the Padres. Pitcher Logan Allen is set to make his season debut on Tuesday after a solid showing in spring training. The Guardians are currently ranked 7th in power rankings, 7th in offense, and 15th in defense, with a record of 2-1 in the season.

San Diego Padres Analysis

The San Diego Padres kicked off their 2025 season with an impressive four-game series sweep against the Atlanta Braves. The Padres dominated offensively, outscoring the Braves 17-7 and showcasing a strong .270/.336/.418 triple-slash. Standout performances from RF Fernando Tatis Jr. and CF Jackson Merrill contributed to the team's success. Pitcher Michael King, who is set to start on Tuesday night, had a solid 2024 season with a 2.95 ERA and a 1.19 WHIP. Despite facing some tough competition, the Padres currently hold a power ranking of 4 and are undefeated at 4-0. In their last matchup, the Padres emerged victorious against Cleveland, who went 2-1 in their last three matchups against San Diego.

Michael Kings Impressive Spring Training Sets High Expectations for Opening Day Matchup Against Guardians

Michael Kings had a solid spring training performance with a 3.95 ERA and 1.02 WHIP in 13.2 innings. His upcoming performance is expected to improve from Opening Day. The current statistics show the Guardians batting 4-for-32 against King, indicating a potential advantage for the Padres on the runline. However, the moneyline odds are less favorable. King previously faced the Guardians in 2024, leading to a 2-1 victory for his team with a strong pitching performance. On the contrary, Logan Allen faced the Padres in 2023 and struggled, giving up five earned runs in three innings. The Padres bullpen demonstrated impressive performance recently, with a 3-0 record, 0.56 ERA, and 0.69 WHIP in 16 innings. In comparison, the Guardians' bullpen went 1-1 with a 2.38 ERA and 1.41 WHIP over 11.1 innings in their previous series against the Royals.

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