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  1. Home
  2. MLB Picks
  3. San Francisco Giants vs Houston Astros
Tue 8:10 PM ET
San Francisco Giants logo
San Francisco
Giants3
L. Webb RHP
versus
Houston Astros logo
Houston
Astros1
H. Wesneski RHP
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San Francisco Giants vs Houston Astros Betting Picks & Predictions

Game time: April 1, 2025 at 8:10 PM ET

Venue: Daikin Park — Houston, Texas

Article updated Apr 1, 6:17 AM EDT

Published by SportsJaw Editorial Team

The San Francisco Giants will be facing the Houston Astros in the second game of their interleague series at Daikin Park on Tuesday night. The Giants are looking to secure

Game outlook

The San Francisco Giants will be facing the Houston Astros in the second game of their interleague series at Daikin Park on Tuesday night. The Giants are looking to secure their second consecutive series win, with Logan Webb taking the mound with a 5.40 ERA. The Astros will be starting Hayden Wesneski, who has yet to make a start this season after posting a 3.86 ERA last year. San Francisco holds a 6-4 record in their last 10 games against Houston. The Giants are currently favored in the betting lines at -117. Stay tuned to see which team comes out on top in this matchup.

Betting Odds

Moneyline: Giants -117 | Astros +100

Spread: Giants -1.5 (+145) | Astros +1.5 (-167)

Total: Over/Under 8 (-110)

Based on the moneyline, the implied probability that San Francisco will win straight-up is 54%.

San Francisco Giants

The San Francisco Giants have started the season strong, winning two out of their first three games. They are currently on a three-game winning streak over the Astros and will look to extend that to four games in their upcoming match on Tuesday. The Giants are averaging 4.67 runs per game, ranking eighth in the league, with a .214 batting average (19th in the league), .250 on-base percentage (28th), and .408 slugging percentage (10th). Heliot Ramos leads the team with a .333 batting average, while Wilmer Flores leads in home runs and RBI. On the defensive side, they are giving up 3.33 runs per game (15th), with opponents having a .221 batting average (15th), a 3.46 ERA (15th), and a 1.08 WHIP (11th). In their last game, Webb allowed three runs in five innings in a 6-4 win over the Reds. The Giants are currently ranked 18th in offense, 12th in defense, and have a power ranking of 13.

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MLB · San Francisco Giants at Houston Astros

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Houston Astros Analysis

The Houston Astros had a slow start last season but are off to a better start this season, winning two of their first three games. They will face the Giants in an upcoming series as they aim for their second series win. Despite averaging two runs per game and having lower batting averages compared to other teams, the Astros are performing well defensively, giving up only 1.33 runs per game with a strong pitching performance. Jose Altuve leads the team in batting average, Jeremy Pena in home runs, and Yordan Alvarez in RBI. The Astros have a power ranking of 9, ranking 25th in offense and 2nd in defense. In their last three matchups, San Francisco went 1-2 against Houston.

San Francisco Giants Outpacing Houston Astros in Offensive Performance for Advantage on Money Line

The Houston Astros and San Francisco Giants have each won two out of their last three games, with the Giants holding an advantage due to their superior offensive performance. San Francisco has outscored Houston by eight runs, demonstrating their ability to hit the ball effectively. In contrast, Houston has struggled at the plate with a .177 batting average against right-handers. Additionally, the Giants have had success against Wesneski, who has given up 11 runs in his last three starts against them. On the other hand, the Astros have struggled against Webb, winning only one out of four starts against him and allowing six runs in their last three matchups. Given these factors, it is recommended to choose San Francisco on the money line as they are poised to limit Houston's offensive output.

SportsJawGame Predictions
Predicted score

Unavailable for this preview

Projected winnerUnavailableConfidencelow
Pick on the Spread

Published pick: Unavailable

Pick on the Total

Published pick: Unavailable

#SanFranciscoGiants#HoustonAstros

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Written by

SportsJaw Editorial Team

SportsJaw published this archived preview from its original game-day article. Its prediction and quoted lines are preserved as written.

About our editorial process

SportsJaw Giants vs Astros archived game preview contains historical odds and availability that may no longer be current. View history of past Giants vs Astros matchups or learn how our predictions work.

Current matchup data

Lines, trends and availability

Line movement since open

  • Moneyline · San Francisco Giants-117 → -133Moved
  • Moneyline · Houston Astros+100 → +117Moved
  • Spread · San Francisco Giants-1.5 (+145) → -1.5 (+130)Moved
  • Spread · Houston Astros+1.5 (-167) → +1.5 (-147)Moved
  • Total · Over8 (-110) → 8 (-110)Unchanged
  • Total · Under8 (-110) → 8 (-110)Unchanged

ATS and O/U trends

San Francisco Giants
65-97 matchup record · 6-4-0 ATS · 7-2-1 O/U
Last 10 completed games on file
Houston Astros
81-81 matchup record · 3-7-0 ATS · 2-7-1 O/U
Last 10 completed games on file

Injuries and availability

From the published research (2025-04-01T10:17:33.415Z). Availability may have changed; review the cited sources.

No verified injury or availability note was included in the published matchup research.

Recent head-to-head

  • 2025-03-31San Francisco Giants 7 · Houston Astros 2
Final result

Matchup pick recap

San Francisco Giants defeated Houston Astros 3-1

San Francisco Giants defeated Houston Astros 3-1 on April 1, 2025, a 2-run decision in the series. San Francisco Giants' strongest period was the 3rd inning, when it outscored its opponent 2-0. Against SportsJaw's recorded San Francisco Giants -1.5 (+130) spread, San Francisco Giants covered, while the 4 combined runs finished under the recorded total of 8.

SportsJaw editorial picks

  • Projected winnerNo published selectionUnavailable

Tipster picks

  • MaddogMoneyline · San Francisco Giants -117Win
  • Mickey619Moneyline · San Francisco Giants +100Win
  • NutinbutlocksMoneyline · Houston Astros +100Loss
  • JoeyBergMoneyline · San Francisco Giants -118Win
  • RcMoneyline · San Francisco Giants -118Win
  • EXCELent Sports PicksMoneyline · Houston Astros +100Loss
  • EXCELent Sports PicksRunline · Houston Astros +1.5 (-165)Loss
  • MoneymouthTotal · Over 8 (-110)Loss