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  1. Home
  2. MLB Picks
  3. Los Angeles Angels vs St. Louis Cardinals
Tue 7:45 PM ET
Los Angeles Angels logo
Los Angeles
Angels9
K. Hendricks RHP
versus
St. Louis Cardinals logo
St. Louis
Cardinals7
M. Liberatore LHP
Final/11
Team1234567891011T
Los Angeles Angels003000000339
St. Louis Cardinals

Los Angeles Angels vs St. Louis Cardinals Betting Picks & Predictions

Game time: April 1, 2025 at 7:45 PM ET

Venue: Busch Stadium — St. Louis, Missouri

Article updated Apr 1, 6:15 AM EDT

Published by SportsJaw Editorial Team

In this article, we provide a prediction for the middle game of a three-game interleague series between the Angels and Cardinals in St. Louis. The Angels recently won their

Game outlook

In this article, we provide a prediction for the middle game of a three-game interleague series between the Angels and Cardinals in St. Louis. The Angels recently won their season-opening series, while the Cardinals swept their series against Minnesota. The starting pitchers for the game are Kyle Hendricks for the Angels and Matthew Liberatore for the Cardinals. St. Louis is the betting favorite with a -147 opening line that has not moved. This prediction was made prior to the conclusion of the series opener.

Betting Odds

Moneyline: Angels +133 | Cardinals -147

Spread: Angels +1.5 (-165) | Cardinals -1.5 (+145)

Total: Over/Under 8.5 (-110)

Based on the moneyline, the implied probability that St. Louis will win straight-up is 60%.

Los Angeles Angels

The Los Angeles Angels bounced back from a blowout loss on Opening Day to win the final two games of their series against the White Sox. They currently hold a 2-1 record for the season and are tied for second in the AL West, half a game behind the Rangers. In Sunday's victory, the Angels had six hits with Kyren Paris hitting his first home run in the eighth inning to secure the win. Pitcher Jack Kochanowicz threw six solid innings while Ben Joyce earned the win and Kenley Jansen notched his second save. Kyle Hendricks will be making his season and team debut for the Angels, having had a successful spring training. The Angels are ranked 30th in offense, 16th in defense, and currently have a power ranking of 29.

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MLB · Los Angeles Angels at St. Louis Cardinals

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St. Louis Cardinals Analysis

The St. Louis Cardinals opened the season on a positive note by sweeping the Twins at home, improving their record to 3-0 and taking the top spot in the NL Central. The Cardinals showcased a strong offensive performance with key contributions from Pedro Pages, Nolan Gorman, and Victor Scott II, who all hit their first home runs of the season in the victory. Pitchers Andre Pallante and Steven Matz also excelled on the mound, with Matz earning his first save of the season. Matthew Liberatore is set to make his season debut for the Cardinals, following a successful spring training performance. The Cardinals currently hold a power ranking of 5 and are ranked #8 for offense and #5 for defense, with an average of 5.00 points scored and 2.00 points allowed per game. In their last three matchups against Los Angeles, the Cardinals have a record of 2-1.

St. Louis Cardinals Face Tough Competition Against Los Angeles Angels

The St. Louis Cardinals began the season on a positive note, securing three victories against the Minnesota Twins. However, maintaining this success may prove challenging. Liberatore, despite a promising performance in spring training, faced difficulties in his previous outing against the Los Angeles Angels. Similarly, Hendricks has exhibited consistent excellence against the Cardinals throughout his career, indicating a formidable challenge for the St. Louis team, even with his move to an American League franchise. The Angels boast a strong lineup led by notable players such as Mike Trout, Jorge Soler, and Taylor Ward. Additionally, their bullpen demonstrated effectiveness in a recent matchup against the Chicago White Sox, suggesting a competitive advantage in the upcoming game. Ultimately, this solid roster, combined with effective bullpen support, positions the Angels to secure a victory in this contest.

SportsJawGame Predictions
Predicted score

Unavailable for this preview

Projected winnerUnavailableConfidencelow
Pick on the Spread

Published pick: Unavailable

Pick on the Total

Published pick: Unavailable

#LosAngelesAngels#StLouisCardinals

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Written by

SportsJaw Editorial Team

SportsJaw published this archived preview from its original game-day article. Its prediction and quoted lines are preserved as written.

About our editorial process

SportsJaw Angels vs Cardinals archived game preview contains historical odds and availability that may no longer be current. View history of past Angels vs Cardinals matchups or learn how our predictions work.

Current matchup data

Lines, trends and availability

Line movement since open

  • Moneyline · Los Angeles Angels+133 → +120Moved
  • Moneyline · St. Louis Cardinals-147 → -134Moved
  • Spread · Los Angeles Angels+1.5 (-165) → +1.5 (-174)Moved
  • Spread · St. Louis Cardinals-1.5 (+145) → -1.5 (+150)Moved
  • Total · Over8.5 (-110) → 8 (-110)Moved
  • Total · Under8.5 (-110) → 8 (-110)Moved

ATS and O/U trends

Los Angeles Angels
62-100 matchup record · 2-8-0 ATS · 3-6-1 O/U
Last 10 completed games on file
St. Louis Cardinals
77-85 matchup record · 8-2-0 ATS · 6-4-0 O/U
Last 10 completed games on file

Injuries and availability

From the published research (2025-04-01T10:15:27.005Z). Availability may have changed; review the cited sources.

No verified injury or availability note was included in the published matchup research.

Recent head-to-head

  • 2025-03-31Los Angeles Angels 5 · St. Louis Cardinals 4
Final result

Matchup pick recap

Los Angeles Angels defeated St. Louis Cardinals 9-7

Los Angeles Angels defeated St. Louis Cardinals 9-7 on April 1, 2025, a 2-run decision in the series. Los Angeles Angels' strongest period was the 3rd inning, when it outscored its opponent 3-0. Against SportsJaw's recorded Los Angeles Angels +1.5 (-174) spread, Los Angeles Angels covered, while the 16 combined runs finished over the recorded total of 8.

SportsJaw editorial picks

  • Projected winnerNo published selectionUnavailable

Tipster picks

  • PeytoncMoneyline · St. Louis Cardinals -147Loss
  • DrpaulTotal · Over 8.5 (-110)Win
  • JeffjacksonMoneyline · Los Angeles Angels +131Win
  • 4923648320Moneyline · Los Angeles Angels +126Win
  • EXCELent Sports PicksMoneyline · St. Louis Cardinals -144Loss