Cleveland Guardians vs
San Diego PadresPredictions & Preview

Guardians Aim for Victory Against Padres in Interleague Matchup: Ortiz vs. Hart on the Mound

In this interleague matchup between the Cleveland Guardians and the San Diego Padres, the Guardians are coming off a 6-2 win against the Royals while the Padres are looking for a sweep after a 1-0 victory over the Braves. Last season, the Padres won two out of three meetings between the teams. Luis Ortiz will be pitching for the Guardians and Kyle Hart for the Padres. San Diego is favored to win with a -130 opening line that has remained unchanged. Stay tuned for our Guardians vs. Padres prediction.

Betting Odds

• Moneyline: Guardians +115 | Padres -130
• Spread: Guardians +1.5 (-178) | Padres -1.5 (+155)
• Total: Over/Under 8 (-110)
• Based on the moneyline, the implied probability that San Diego will win straight-up is 57%.

Cleveland vs San Diego Stats

Cleveland Guardians

Cleveland ended their season-opening series on a positive note with a victory against the Royals, improving their record to 2-1 and holding the top spot in the AL Central. The team had a strong offensive performance, with Steven Kwan, Kyle Manzardo, and Gabriel Arias each contributing multiple hits and runs in the win. Pitcher Tanner Bibee earned the win with a solid performance on the mound. Luis Ortiz is set to make his first start of the season, coming off a successful season with the Pirates and a challenging spring training. Ortiz has struggled in past matchups against the Padres, including a loss at Petco Park in 2024. Cleveland is currently ranked 13th in power rankings, with a strong offense but weaknesses on defense. They have a record of 1-1 so far this season.

San Diego Padres Analysis

The San Diego Padres defeated Atlanta in a pitchers' duel on Saturday night, improving their record to 3-0 for the season. They are currently second in the NL West, one game behind the Dodgers. San Diego finished with just four hits in the game, with Yuli Gurriel providing the lone run with a pinch hit RBI single in the seventh inning. Pitchers Randy Vasquez and Wandy Peralta were instrumental in securing the win. Adrian Morejon earned his first save of the season. Kyle Hart, making his debut for the Padres after a successful season in the KBO, will be starting the next game against the Guardians. The Padres have a power ranking of 6 and are ranked #8 for offense, scoring an average of 5.50 runs per game, and #13 for defense, giving up an average of 3.50 runs per game.

Cleveland Guardians Favored to Win Against Uncertain Padres Pitcher

San Diego has been on a hot streak in their first three games this season, however, the performance of Hart in his upcoming big league outing remains uncertain. Hart's previous four major league appearances during the COVID-shortened 2020 season were disappointing, as he recorded an ERA exceeding 15 in those games. While Ortiz may not be a standout player, he is a reliable pitcher who can help his team stay competitive. With a strong lineup, the Guardians are capable of keeping pace with the Padres. Given Hart's lack of proven success at this level, it may be advisable to bet against him. Therefore, the Cleveland team is favored to win this contest and take an early lead in the series.

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