Minnesota Twins vs
St. Louis CardinalsPredictions & Preview

Minnesota Twins vs. St. Louis Cardinals: 2025 MLB Season Kicks Off with Intriguing Interleague Matchup

The 2025 Major League Baseball season begins with most teams playing their first game, including the Minnesota Twins facing off against the St. Louis Cardinals in a three-game interleague series. Pablo Lopez will start for the Twins, while Sonny Gray will take the mound for the Cardinals. St. Louis is favored to win, with a current line of Minnesota -108. Stay tuned to see which team comes out on top in this Minnesota vs. St. Louis matchup.

Betting Odds

• Moneyline: Twins -108 | Cardinals -106
• Spread: Twins -1.5 (+159) | Cardinals +1.5 (-186)
• Total: Over/Under 7.5 (-110)
• Based on the moneyline, the implied probability that Minnesota will win straight-up is 52%.

Minnesota vs St. Louis Stats

Minnesota Twins

The Minnesota Twins improved significantly this season, winning the AL Central in 2023 after finishing fourth last year. Despite not making any major moves in free agency, the team focused on retaining their core players in hopes of returning to the playoffs. Last season, their offense ranked 10th in the league with an average of 4.58 runs per game, while their pitching struggled, allowing 4.21 runs per game. Lopez was a standout pitcher for the Twins last season. Currently, with a power ranking of 26, Minnesota ranks 10th in offense and 19th in defense, with a record of 0-0 this season.

St. Louis Cardinals Analysis

The St. Louis Cardinals won the NL Central in 2022 but finished at the bottom of the division in 2023. They bounced back with an 83-win season last year but missed the playoffs for the second straight year. The team is aiming to improve on last season's success and end their playoff drought this season. Despite a quiet offseason, where they kept most of last season's roster and acquired utility man Michael Helman, they are hoping for continued success. St. Louis had a 12-win improvement last season and is looking to challenge Milwaukee for the division title. The Cardinals had a stronger pitching performance last season compared to their offense. They will rely on standout pitcher Gray, who had 13 wins last season. With a power ranking of 8, the Cardinals rank 22nd in offense and 18th in defense. They are currently 0-0 overall and had a 2-1 record in their last three matchups against Minnesota.

Minnesota Twins Set to Dominate with Strong Batting and Pitching Edge Against St. Louis Cardinals

Both teams made minimal enhancements to their rosters during the offseason. The Minnesota Twins have an advantage due to their strong batting performance against right-handed pitchers last season, boasting a .242 batting average. Despite his past success, Sonny Gray struggled in Spring Training with an ERA exceeding 10 and has a history of difficulties against the Twins, allowing 10 runs in his last three starts against them. Conversely, Twins' pitcher Lopez had a strong showing in Spring Training and has proven success against the St. Louis Cardinals, conceding only six runs in his four previous starts against them. Having only allowed one run in his last two starts against the Cardinals, Lopez is poised to stifle their offense once more. It is advisable to bet on the Minnesota Twins to cover the money line in this game.

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