| Score | Moneyline | Spread | Game total | |
|---|---|---|---|---|
| Indianapolis ColtsIND | 20 | +160 L | +3.5 (-110) L | O 49.5 (-110) L U 49.5 (-110) W |
| Los Angeles RamsLAR | 27 | -185 W | -3.5 (-110) W |
Los Angeles Rams defeated Indianapolis Colts 27-20
Los Angeles Rams defeated Indianapolis Colts 27-20 on September 28, 2025, a 7-point decision in the series. Los Angeles Rams' strongest period was the 4th quarter, when it outscored its opponent 14-10. Against SportsJaw's recorded Indianapolis Colts +3.5 (-110) spread, Los Angeles Rams covered, while the 47 combined points finished under the recorded total of 49.5.
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