| Score | Moneyline | Spread | Game total | |
|---|---|---|---|---|
| Buffalo BillsBUF | 40 | -400 W | -7 (-110) W | O 47.5 (-110) W U 47.5 (-110) L |
| Carolina PanthersCAR | 9 | +310 L | +7 (-110) L |
Buffalo Bills defeated Carolina Panthers 40-9
Buffalo Bills defeated Carolina Panthers 40-9 on October 26, 2025, a 31-point decision in the series. Buffalo Bills' strongest period was the 3rd quarter, when it outscored its opponent 21-0. Against SportsJaw's recorded Buffalo Bills -7 (-110) spread, Buffalo Bills covered, while the 49 combined points finished over the recorded total of 47.5.
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