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Cowboys vs. Giants: Week 1 injuries leave the betting call at Pass
The New York Giants host the Dallas Cowboys at MetLife Stadium on Sunday, September 13, in Week 1 of the 2026 NFL regular season. Giants.com lists kickoff at 8:20 p.m. ET.
Dak Prescott begins his 11th season as Dallas’ starting quarterback. According to DallasCowboys.com, he has won 14 of his 17 career starts against the Giants. CeeDee Lamb and George Pickens also return for their second season together. Those facts provide context, but Prescott’s historical record does not establish the probability of a Dallas win in this matchup.
New York opens John Harbaugh’s tenure with Jaxson Dart making his first Week 1 start. Dennard Wilson is the Giants’ defensive coordinator, while Dallas also has a new defensive coordinator in Christian Parker.
The Giants list Malik Nabers as questionable with a knee injury despite full participation in practice Wednesday through Friday. His practice participation does not confirm that he will play.
DallasCowboys.com reports that left guard Tyler Smith needs thumb surgery and is expected to go on injured reserve with a designation to return. T.J. Bass is the expected replacement. Running back Malik Davis is out with a hip injury after earning the backup role behind Javonte Williams. Dallas has added Emari Demercado and could elevate Israel Abanikanda.
Dallas is -3 (-110) and -160 on the moneyline. New York is +3 (-110) and +140. Over 48 is priced at -110, and under 48 is priced at -110.
The available reporting does not establish a sufficient advantage against those prices. It also provides no dependable basis for estimating scoring or choosing either side of the total. The betting lean is Pass, with no winner or score prediction. Confidence in a betting recommendation remains low.