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NFL MatchupsThu 8:15 PM ET
Detroit
Lions
9-8
VS
Buffalo
Bills
12-5
Game preview ↓
NFL · DET at BUF

Your Picks on Lions vs Bills

Picks close 15 minutes before game time (ET)
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NFL · Last 30 days

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Roycejacobs profile

Roycejacobs

Win %
100.0%
Units won
+909
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Emc profile

Emc

Win %
100.0%
Units won
+909
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Geauxtigers profile

Geauxtigers

Win %
100.0%
Units won
+909
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Sarah_Miller profile

Sarah_Miller

Win %
100.0%
Units won
+909
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Detroit Lions vs Buffalo Bills Predictions

Game date: September 17, 2026

By SportsJaw Editorial Team

Detroit Lions at Buffalo Bills

Game outlook

The current spread lists Detroit Lions at +3 (-110) and Buffalo Bills at -3 (-110). These are market lines, not a SportsJaw recommendation.

The total is 51.5 (-110) for the over and 51.5 (-110) for the under. A total pick concerns the teams’ combined score, independently of which team wins.

Opening vs current

DET: opening spread +3 (-110); current spread +3 (-110). BUF: opening spread -3 (-110); current spread -3 (-110).

Opening over: 52.5 (-110). Current over: 51.5 (-110). Line changes alone do not establish an injury, lineup change, or betting advantage.

Moneyline

Detroit Lions: +143. Buffalo Bills: -168. Moneyline picks concern the outright winner rather than the winning margin.

Analysis status

A full SportsJaw game analysis has not been published for this matchup. Verified matchup factors, injury news, a projected score, and a recommended pick will appear only when supported by published analysis. The values here come directly from the current SportsJaw event record.

Current spreadDET +3 (-110)BUF -3 (-110)
MoneylineDET +143BUF -168
Total points51.5 (-110)
Projected score

No published projected score or confidence rating is available for this matchup.

SportsJaw Lions vs Bills game preview includes current market data. Lines and player availability can change. Please confirm current information before wagering. How our predictions work