| Score | Moneyline | Spread | Game total | |
|---|---|---|---|---|
| Los Angeles ChargersLAC | 18 | -270 L | -6 (-110) L | O 42.5 (-110) L U 42.5 (-110) W |
| New York GiantsNYG | 21 | +220 W | +6 (-110) W |
New York Giants defeated Los Angeles Chargers 21-18
New York Giants defeated Los Angeles Chargers 21-18 on September 28, 2025, a 3-point decision in the series. New York Giants' strongest period was the 1st quarter, when it outscored its opponent 7-0. Against SportsJaw's recorded Los Angeles Chargers -6 (-110) spread, New York Giants covered, while the 39 combined points finished under the recorded total of 42.5.
| Team | 1 | 2 | 3 | 4 | T |
|---|---|---|---|---|---|
| LAC | 0 | 10 | 8 | 0 | 18 |
| NYG | 7 | 6 | 8 | 0 | 21 |


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