| Score | Moneyline | Spread | Game total | |
|---|---|---|---|---|
| Kansas City ChiefsKC | 22 | -295 W | -6 (-110) W | O 44.5 (-110) L U 44.5 (-110) W |
| New York GiantsNYG | 9 | +241 L | +6 (-110) L |
Kansas City Chiefs defeated New York Giants 22-9
Kansas City Chiefs defeated New York Giants 22-9 on September 21, 2025, a 13-point decision in the series. Kansas City Chiefs' strongest period was the 3rd quarter, when it outscored its opponent 7-0. Against SportsJaw's recorded Kansas City Chiefs -6 (-110) spread, Kansas City Chiefs covered, while the 31 combined points finished under the recorded total of 44.5.
| Team | 1 | 2 | 3 | 4 | T |
|---|---|---|---|---|---|
| KC | 3 | 6 | 7 | 6 | 22 |
| NYG | 0 | 6 | 0 | 3 | 9 |


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