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Bills at Texans: Pass on the Week 1 betting line
The Buffalo Bills visit the Houston Texans on September 13 for Week 1 of the 2026 NFL season. Buffalo is listed at -1.5 (-110) and -120 on the moneyline. Houston is +1.5 (-110) and +105. Both over and under 44.5 are priced at -110.
Houston won last season’s meeting 23-19 with eight sacks, according to Buffalo’s matchup report. The Bills have also lost their last five regular-season games in Houston. Those results provide context, but they do not establish how this game will unfold.
Buffalo’s offense ranked fourth in scoring last season and added receivers DJ Moore and Skyler Bell. Joe Brady now begins his first regular-season game as Buffalo’s head coach.
Buffalo’s preview describes Houston’s defense as first in the NFL last season, without specifying the ranking category. The Texans added Reed Blankenship, Logan Hall and Kayden McDonald. Their previous success pressuring Josh Allen is relevant, but assuming another eight-sack performance would overstate that history.
Houston also invested in its offensive line and added running back David Montgomery. Buffalo enters its first game under defensive coordinator Jim Leonhard after allowing 136.2 rushing yards per game and 5.1 yards per carry last season. Those figures identify a previous weakness, not proof that Houston’s revised offense will exploit it.
Houston receiver Jayden Higgins is unavailable following an ACL tear. Buffalo lists Ty Johnson, T.J. Sanders and Jordan Hancock as questionable; those designations do not establish that they will miss the game.
The available information supports competing matchup arguments but does not establish value on either side or the total. Houston’s history alone cannot justify calling +1.5 the superior wager. Pass, with no winner or projected score selected.