| Score | Moneyline | Spread | Game total | |
|---|---|---|---|---|
| Northwestern WildcatsNWESTN | 17 | +458 L | +14 (-110) L | O 54 (-110) W U 54 (-110) L |
| USC TrojansUSC | 38 | -625 W | -14 (-110) W |
USC Trojans defeated Northwestern Wildcats 38-17
USC Trojans defeated Northwestern Wildcats 38-17 on November 7, 2025, a 21-point decision in the series. USC Trojans' strongest period was the 4th quarter, when it outscored its opponent 10-0. Against SportsJaw's recorded Northwestern Wildcats +14 (-110) spread, USC Trojans covered, while the 55 combined points finished over the recorded total of 54.
| Team | 1 | 2 | 3 | 4 | T |
|---|---|---|---|---|---|
| Northwestern Wildcats | 7 | 7 | 3 | 0 | 17 |
| USC Trojans | 7 | 14 | 7 | 10 | 38 |

