| Score | Moneyline | Spread | Game total | |
|---|---|---|---|---|
| Michigan St. SpartansMICHST | 31 | +620 L | +18.5 (-110) W | O 55.5 (-110) W U 55.5 (-110) L |
| USC TrojansUSC | 45 | -950 W | -18.5 (-110) L |
USC Trojans defeated Michigan St. Spartans 45-31
USC Trojans defeated Michigan St. Spartans 45-31 on September 20, 2025, a 14-point decision in the series. USC Trojans' strongest period was the 2nd quarter, when it outscored its opponent 14-3. Against SportsJaw's recorded Michigan St. Spartans +18.5 (-110) spread, Michigan St. Spartans covered, while the 76 combined points finished over the recorded total of 55.5.

