| Score | Moneyline | Spread | Game total | |
|---|---|---|---|---|
| Holy Cross Crusadershc | 30 | -250 W | -6.5 (-110) W | O 46.5 (-110) W U 46.5 (-110) L |
| Harvard Crimsonharv | 21 | +200 L | +6.5 (-110) L |
Holy Cross Crusaders defeated Harvard Crimson 30-21
Holy Cross Crusaders defeated Harvard Crimson 30-21 on October 1, 2022, a 9-point decision in the series. Holy Cross Crusaders' strongest period was the 4th quarter, when it outscored its opponent 6-0. Against SportsJaw's recorded Holy Cross Crusaders -6.5 (-110) spread, Holy Cross Crusaders covered, while the 51 combined points finished over the recorded total of 46.5.

