| Score | Moneyline | Spread | Game total | |
|---|---|---|---|---|
| Wyoming CowboysWYO | 20 | +350 L | +12 (-110) L | O 46 (-110) W U 46 (-110) L |
| Colorado BuffaloesCOLO | 37 | -463 W | -12 (-110) W |
Colorado Buffaloes defeated Wyoming Cowboys 37-20
Colorado Buffaloes defeated Wyoming Cowboys 37-20 on September 20, 2025, a 17-point decision in the series. Colorado Buffaloes' strongest period was the 2nd quarter, when it outscored its opponent 21-3. Against SportsJaw's recorded Wyoming Cowboys +12 (-110) spread, Colorado Buffaloes covered, while the 57 combined points finished over the recorded total of 46.
| Team | 1 | 2 | 3 | 4 | T |
|---|---|---|---|---|---|
| Wyoming Cowboys | 0 | 3 | 10 | 7 | 20 |
| Colorado Buffaloes | 0 | 21 | 7 | 9 | 37 |

